Publication Name	World Journal of Gastroenterology
Manuscript ID	25664
Country	Spain

Received	2016-03-18 08:39
Peer-Review Started	2016-03-21 16:18
To Make the First Decision	2016-05-12 09:14
Return for Revision	2016-05-16 15:58
Revised	2016-05-26 23:23
Second Decision	2016-06-06 08:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-06-15 17:48
Articles in Press	2016-06-15 17:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-28 11:11
Publish the Manuscript Online	2016-07-04 14:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatopulmonary syndrome: What we know and what we would like to know
Manuscript Source	Invited Manuscript
All Author List	Israel Grilo-Bensusan and Juan Manuel Pascasio-Acevedo
Funding Agency and Grant Number
Corresponding Author	Israel Grilo-Bensusan, MD, PhD, Digestive Diseases Department, HAR, Écija, APS Bajo Guadalquivir, Avda, de los Emigrantes 24, Piso: 2º E, Écija, 41400 Seville, Spain. igrilob@telefonica.net
Key Words	Hepatopulmonary syndrome; Liver cirrhosis; Liver transplantation; Contrast echocardiography; Macroaggregated albumin lung perfusion scan
Core Tip	Hepatopulmonary syndrome is a frequent complication which influences the quality of life and ultimately the survival of patients with cirrhosis. Knowledge about the condition is still limited and this complicates clinical decision making. The most widely used methods for establishing a diagnosis are an arterial blood gas analysis and a contrast echocardiography. There is currently no effective medical treatment and other means of supporting patients have barely been evaluated. liver transplantation has been demonstrated to reverse it and improve survival levels, although there are controversies in the policies of prioritization in terms of the waiting lists for transplantation. This review examines current knowledge about the syndrome from a practical and analytical approach.
Publish Date	2016-07-04 14:42
Citation	Grilo-Bensusan I, Pascasio-Acevedo JM. Hepatopulmonary syndrome: What we know and what we would like to know. World J Gastroenterol 2016; 22(25): 5728-5741
URL	http://www.wjgnet.com/1007-9327/full/v22/i25/5728.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i25.5728

Full Article (PDF)	WJG-22-5728.pdf
Full Article (Word)	WJG-22-5728.doc
Manuscript File	25664-Review.doc
Answering Reviewers	25664-Answering reviewers.pdf
Audio Core Tip	25664-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25664-Conflict-of-interest statement.pdf
Copyright License Agreement	25664-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25664-Language certificate.pdf
Peer-review Report	25664-Peer-review(s).pdf
Scientific Misconduct Check	25664-Scientific misconduct check.pdf
Scientific Editor Work List	25664-Scientific editor work list.pdf