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7/15/2016 3:38:00 PM | Browse: 1190 | Download: 2409
Publication Name World Journal of Gastroenterology
Manuscript ID 25780
Country/Territory Brazil
Received
2016-03-22 15:44
Peer-Review Started
2016-03-23 11:18
To Make the First Decision
2016-04-14 10:09
Return for Revision
2016-04-14 14:26
Revised
2016-05-19 00:00
Second Decision
2016-05-23 08:45
Accepted by Journal Editor-in-Chief
2016-05-26 05:46
Accepted by Company Editor-in-Chief
2016-06-15 18:35
Articles in Press
2016-06-15 18:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-07-08 10:13
Publish the Manuscript Online
2016-07-15 15:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Immunohistochemistry panel segregates molecular types of hepatocellular carcinoma in Brazilian autopsy cases
Manuscript Source Unsolicited Manuscript
All Author List Aloísio Felipe-Silva, Alda Wakamatsu, Cinthya dos Santos Cirqueira and Venâncio Avancini Ferreira Alves
Funding Agency and Grant Number
Funding Agency Grant Number
Fundação de Amparo a Pesquisa do Estado de São Paulo 08/58855-3 to Alves VAF
Corresponding Author Aloísio Felipe-Silva, MD, PhD, LIM 14-Patologia Hepática, Faculdade de Medicina da USP, Avenida Dr. Arnaldo 455 1o. Andar Sala 1157, 01246-903 São Paulo SP, Brazil. aloisiosilva@hu.usp.br
Key Words Hepatocellular carcinoma; Epidermal growth factor receptor; Autopsy; Immunohistochemistry; Liver; Classification
Core Tip This study assessed the immunohistochemistry-detected expression of several protein products of genes known to be involved in the molecular pathogenesis of hepatocellular carcinoma (HCC) in a retrospective autopsy cohort of patients with HCC. The data showed that expression profiles of these markers may be related to different pathways underlying HCC progression and metastasis, and that the Edmondson-Steiner’s tumor grade may reflect currently recognized molecular subclasses of HCC. This cross-sectional analysis supports the strategy of translating genomic data into panels of immunohistochemical markers for risk evaluation in HCC and also reinforces the paramount importance of histological grade in this context.
Publish Date 2016-07-15 15:38
Citation Felipe-Silva A, Wakamatsu A, dos Santos Cirqueira C, Alves VAF. Immunohistochemistry panel segregates molecular types of hepatocellular carcinoma in Brazilian autopsy cases. World J Gastroenterol 2016; 22(27): 6246-6256
URL http://www.wjgnet.com/1007-9327/full/v22/i27/6246.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i27.6246
Full Article (PDF) WJG-22-6246.pdf
Full Article (Word) WJG-22-6246.doc
Manuscript File 25780-Review.docx
Answering Reviewers 25780-Answering reviewers.pdf
Audio Core Tip 25780-Audio core tip.mp3
Biostatistics Review Certificate 25780-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 25780-Conflict-of-interest statement.pdf
Copyright License Agreement 25780-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 25780-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 25780-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 25780-Language certificate.pdf
Supplementary Material Supplementary_Material_20160322154311.pdf
Peer-review Report 25780-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 25780-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 25780-Scientific misconduct check.pdf
Scientific Editor Work List 25780-Scientific editor work list.pdf