Publication Name	World Journal of Gastroenterology
Manuscript ID	26185
Country	Taiwan

Received	2016-03-30 11:48
Peer-Review Started	2016-04-05 12:59
To Make the First Decision	2016-05-12 15:34
Return for Revision	2016-05-13 17:15
Revised	2016-06-20 20:18
Second Decision	2016-07-08 08:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-07-21 16:15
Articles in Press	2016-07-21 16:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-11 15:00
Publish the Manuscript Online	2016-08-24 10:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Shih-Hung Yang, Ting-Chun Kuo, Hsu Wu, Jhe-Cyuan Guo, Chiun Hsu, Chih-Hung Hsu, Yu-Wen Tien, Kun-Huei Yeh, Ann-Lii Cheng and Sung-Hsin Kuo
Funding Agency and Grant Number
Corresponding Author	Sung-Hsin Kuo, MD, PhD, Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, No. 7, Chung-Shan South Road, Taipei 100, Taiwan. shkuo101@ntu.edu.tw
Key Words	Radiotherapy; Pancreatic cancer; DNA damage; DNA repair; Molecular targets
Core Tip	Radiotherapy causes DNA damage, including double-strand breaks, which is more readily repaired in normal cells than in cancerous cells. Radiosensitization, using DNA repair pathway inhibitors, has been well documented in various cancer types, including pancreatic cancer. Further development of optimal protocols, for the combined use of these inhibitors with radiotherapy, with/without chemotherapy, is warranted for the clinical treatment of pancreatic cancer.
Publish Date	2016-08-24 10:09
Citation	Yang SH, Kuo TC, Wu H, Guo JC, Hsu C, Hsu CH, Tien YW, Yeh KH, Cheng AL, Kuo SH. Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer. World J Gastroenterol 2016; 22(32): 7275-7288
URL	http://www.wjgnet.com/1007-9327/full/v22/i32/7275.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i32.7275

Full Article (PDF)	WJG-22-7275.pdf
Full Article (Word)	WJG-22-7275.doc
Manuscript File	26185-Review.docx
Answering Reviewers	26185-Answering reviewers.pdf
Audio Core Tip	26185-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26185-Conflict-of-interest statement.pdf
Copyright License Agreement	26185-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	26185-Language certificate.pdf
Peer-review Report	26185-Peer-review(s).pdf
Scientific Misconduct Check	26185-Scientific misconduct check.pdf
Scientific Editor Work List	26185-Scientific editor work list.pdf