Publication Name	World Journal of Gastroenterology
Manuscript ID	26269
Country	Mexico

Received	2016-04-01 08:35
Peer-Review Started	2016-04-06 16:47
To Make the First Decision	2016-06-20 14:03
Return for Revision	2016-06-20 16:11
Revised	2016-07-06 04:11
Second Decision	2016-07-27 19:33
Accepted by Journal Editor-in-Chief	2016-07-28 00:41
Accepted by Company Editor-in-Chief	2016-08-05 17:47
Articles in Press	2016-08-05 17:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-07 11:41
Publish the Manuscript Online	2016-09-14 19:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	New insights into the pathophysiology of achalasia and implications for future treatment
Manuscript Source	Invited Manuscript
All Author List	Janette Furuzawa-Carballeda, Samuel Torres-Landa, Miguel Ángel Valdovinos, Enrique Coss-Adame, Luis A Martín del Campo and Gonzalo Torres-Villalobos
Funding Agency and Grant Number
Corresponding Author	Gonzalo Torres-Villalobos, MD, PhD, Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Col. Belisario Domínguez Sección XVI, Mexico City, CP 14080, Mexico. torresvgm@yahoo.com.mx
Key Words	Achalasia; Treatment; Autoimmune disease; Pathophysiology
Core Tip	Primary achalasia is associated with loss of ganglion cells in the esophagus and in the lower esophageal sphincter. In the last decade, achalasia pathophysiology has been widely studied, and investi-gations have aimed to expand clinical management beyond mere treatment of symptoms and towards attacking the specific cause of the disease. While the etiologies remain unclear and no cure exists, the most recent findings suggest an interaction between autoimmune and inflammatory responses, possibly triggered by viral infection, in genetically susceptible individuals. This article reviews the recent advances in understanding the disease pathogenesis with implications for improving therapeutic management.
Publish Date	2016-09-14 19:04
Citation	Furuzawa-Carballeda J, Torres-Landa S, Valdovinos MA, Coss-Adame E, Martín del Campo LA, Torres-Villalobos G. New insights into the pathophysiology of achalasia and implications for future treatment. World J Gastroenterol 2016; 22(35): 7892-7907
URL	http://www.wjgnet.com/1007-9327/full/v22/i35/7892.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i35.7892

Full Article (PDF)	WJG-22-7892.pdf
Full Article (Word)	WJG-22-7892.doc
Manuscript File	26269-Review.doc
Answering Reviewers	26269-Answering reviewers.pdf
Audio Core Tip	26269-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26269-Conflict-of-interest statement.pdf
Copyright License Agreement	26269-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20160401034527.pdf
Peer-review Report	26269-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26269-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26269-Scientific misconduct check.pdf
Scientific Editor Work List	26269-Scientific editor work list.pdf