Publication Name	World Journal of Transplantation
Manuscript ID	2649
Country	Netherlands

Received	2013-03-06 09:20
Peer-Review Started	2013-03-06 21:57
To Make the First Decision	2013-04-16 09:08
Return for Revision	2013-04-18 16:59
Revised	2013-05-28 03:38
Second Decision	2013-06-18 10:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-06-19 00:29
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-18 18:21
Publish the Manuscript Online	2013-08-22 16:37

ISSN	2220-3230 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	mTOR signaling in liver regeneration: Rapamycin combined with growth factor treatment
Manuscript Source	Invited Manuscript
All Author List	Suomi MG Fouraschen, Petra E de Ruiter, Jaap Kwekkeboom, Ron WF de Bruin, Geert Kazemier, Herold J Metselaar, Hugo W Tilanus, Luc JW van der Laan and Jeroen de Jonge
Funding Agency and Grant Number	Funding Agency Grant Number Erasmus MC Grant Liver Research Foundation (SLO) Rotterdam
Corresponding Author	Dr. Luc JW van der Laan, Department of Surgery and Laboratory of Experimental Transplantation and Intestinal Surgery, Erasmus MC-University Medical Center, ‘s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands. l.vanderlaan@erasmusmc.nl
Key Words	Hepatocyte proliferation; Autophagy; Microtubule-associated protein 1 light chain 3; Partial hepatectomy; Rapamycin
Core Tip	Interference of immunosuppressive medication with liver regeneration is a highly relevant issue for transplantation of small-for-size liver grafts. Inhibition of mammalian target of rapamycin (mTOR) represents an important immunosuppressive strategy after transplantation, yet as mTOR regulates cell proliferation and autophagy, concerns remain regarding a negative impact on regeneration. The exact role of mTOR signaling after living-donor liver transplantation is largely unknown. Here we report that mTOR inhibition by rapamycin severely impairs liver regeneration and increases autophagy after liver resection in mice. The most novel finding of this study is that this impaired regeneration can be partly reversed by treatment with exogenous growth factors.
Publish Date	2013-08-22 16:37
Citation	Fouraschen SMG, de Ruiter PE, Kwekkeboom J, de Bruin RWF, Kazemier G, Metselaar HJ, Tilanus HW, van der Laan LJW, de Jonge J. mTOR signaling in liver regeneration: Rapamycin combined with growth factor treatment. World J Transplant 2013; 3(3): 36-47
URL	http://www.wjgnet.com/2220-3230/full/v3/i3/36.htm
DOI	http://dx.doi.org/10.5500/wjt.v3.i3.36

Full Article (PDF)	WJT-3-36.pdf
Manuscript File	2649-Review.doc
Answering Reviewers	2649-Answering reviewers.pdf
Copyright License Agreement	2649-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	105-08-06 Brief verlenging DEC-advies.doc
Peer-review Report	2649-Peer review(s).pdf
Scientific Editor Work List	2649-Scientific editor work list.doc