Publication Name	World Journal of Stem Cells
Manuscript ID	26781
Country	Japan

Received	2016-04-26 08:40
Peer-Review Started	2016-04-27 16:29
To Make the First Decision	2016-05-16 11:04
Return for Revision	2016-05-17 18:01
Revised	2016-06-08 16:51
Second Decision	2016-06-27 16:50
Accepted by Journal Editor-in-Chief	2016-06-28 08:44
Accepted by Company Editor-in-Chief	2016-07-13 13:42
Articles in Press	2016-07-13 13:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-10 12:03
Publish the Manuscript Online	2016-08-19 16:02

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Developmental Biology
Manuscript Type	Minireviews
Article Title	Reprogramming of germ cells into pluripotency
Manuscript Source	Invited Manuscript
All Author List	Yoichi Sekita, Toshinobu Nakamura and Tohru Kimura
Funding Agency and Grant Number	Funding Agency Grant Number Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and Takeda Science Foundation
Corresponding Author	Tohru Kimura, PhD, Professor, Labo­ratory of Stem Cell Biology, Department of Biosciences, Kitasato University School of Science, 1-15-1, Kitasato, Minami-ku, Saga­mihara, Kanagawa 252-0373, Japan. tkimura@kitasato-u.ac.jp
Key Words	Primordial germ cell; Embryonic germ cell; Germ cell tumor; Reprogramming; Induced pluripotent stem cell; Small molecule compound; Gene; Signal; Transcription factor
Core Tip	Primordial germ cells can be reprogrammed into pluripotent stem cells called as embryonic germ cells in vitro and into pluripotent germ cell tumors in vivo. Germ cell reprogramming can be regulated by signal-ing pathways, including PI3K/Akt signaling, mitogen-activated protein kinase signaling, transforming growth factor-β signaling, RA signaling. These mechanisms are also involved in somatic cell reprogramming, indicating that there exist common regulatory networks regulating germ and somatic cell reprogramming. On the other hand, regulators for germ cell development prevent germ cell dedifferentiation in unique manners.
Publish Date	2016-08-19 16:02
Citation	Sekita Y, Nakamura T, Kimura T. Reprogramming of germ cells into pluripotency. World J Stem Cells 2016; 8(8): 251-259
URL	http://www.wjgnet.com/1948-0210/full/v8/i8/251.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i8.251

Full Article (PDF)	WJSC-8-251.pdf
Full Article (Word)	WJSC-8-251.doc
Manuscript File	26781-Review.doc
Answering Reviewers	26781-Answering reviewers.pdf
Audio Core Tip	26781-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26781-Conflict-of-interest statement.pdf
Copyright License Agreement	26781-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	26781-Grant application form(s).pdf
Peer-review Report	26781-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26781-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26781-Scientific misconduct check.pdf
Scientific Editor Work List	26781-Scientific editor work list.pdf