Publication Name	World Journal of Gastroenterology
Manuscript ID	26795
Country	Belgium

Received	2016-04-27 11:25
Peer-Review Started	2016-04-27 14:27
To Make the First Decision	2016-06-20 14:03
Return for Revision	2016-06-20 16:29
Revised	2016-07-18 18:19
Second Decision	2016-07-30 14:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-08-05 17:50
Articles in Press	2016-08-05 17:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-09 12:08
Publish the Manuscript Online	2016-09-30 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Stijn Van Hees, Peter Michielsen and Thomas Vanwolleghem
Funding Agency and Grant Number	Funding Agency Grant Number Foundation Against Cancer Belgium 2014-087
Corresponding Author	Thomas Vanwolleghem, MD, PhD, Department of Gastroenterology and Hepatology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium. thomas.vanwolleghem@uza.be
Key Words	Hepatocellular carcinoma; Hepatitis B virus infection; Biomarkers; Predictive; Diagnostic; Alpha-fetoprotein; Validation; Limitations; MicroRNA
Core Tip	Regular screening for hepatocellular carci-noma (HCC) in patients at risk improves their survival rates. Currently available screening methods include abdominal ultrasound and alpha-fetoprotein serum levels, but both methods lack diagnostic accuracy. Recent technological advances have enabled the identification of new predictive and diagnostic hepatitis B virus (HBV)-associated HCC biomarkers. Nevertheless, most of the studies conducted so far show design limitations. This review provides an overview on the current understanding and future prospects of circulating predictive and diagnostic biomarkers for HBV-associated HCC.
Publish Date	2016-09-30 18:06
Citation	Van Hees S, Michielsen P, Vanwolleghem T. Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma. World J Gastroenterol 2016; 22(37): 8271-8282
URL	http://www.wjgnet.com/1007-9327/full/v22/i37/8271.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i37.8271

Full Article (PDF)	WJG-22-8271.pdf
Full Article (Word)	WJG-22-8271.doc
Manuscript File	26795-Review.docx
Answering Reviewers	26795-Answering reviewers.pdf
Audio Core Tip	26795-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26795-Conflict-of-interest-statement.pdf
Copyright License Agreement	26795-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	26795-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	26795-Language certificate.PDF
Supplementary Material	Supplementary_Material_20160426191846.pdf
Peer-review Report	26795-Peer-review(s).pdf
Scientific Misconduct Check	26795-Scientific misconduct check.pdf
Scientific Editor Work List	26795-Scientific editor work list.pdf