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9/14/2016 7:04:00 PM | Browse: 1260 | Download: 2207
Publication Name World Journal of Gastroenterology
Manuscript ID 27036
Country/Territory Australia
Received
2016-05-06 09:42
Peer-Review Started
2016-05-06 11:46
To Make the First Decision
2016-06-20 10:51
Return for Revision
2016-06-27 17:02
Revised
2016-07-22 21:36
Second Decision
2016-08-05 10:17
Accepted by Journal Editor-in-Chief
2016-08-06 09:27
Accepted by Company Editor-in-Chief
2016-08-10 15:46
Articles in Press
2016-08-10 15:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-06 17:43
Publish the Manuscript Online
2016-09-14 19:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease
Manuscript Source Invited Manuscript
All Author List Christopher Leung, Chandana B Herath, Zhiyuan Jia, Sof Andrikopoulos, Bronwyn E Brown, Michael J Davies, Leni R Rivera, John B Furness, Josephine M Forbes and Peter W Angus
Funding Agency and Grant Number
Funding Agency Grant Number
National Health and Medical Research Council of Australia 1029990
Corresponding Author Christopher Leung, MBBS, FRACP, Department of Gastroenterology and Hepatology, Austin Health, Austin Hospital, 145 Studley Rd, Heidelberg, Victoria 3084, Australia. chris.leung@y7mail.com
Key Words Advanced glycation end-products; Fructose; Steatohepatitis; Non-alcoholic fatty liver disease; Hepatic fibrosis; Oxidative stress
Core Tip A novel high fructose, high cholesterol diet produces hepatic non-alcoholic steatohepatitis (NASH) with fibrosis in 33 wk and increasing the Advanced glycation end products (AGEs), content of this diet via baking increases hepatic fibrosis whilst vinegar marination decreases dietary AGE levels, abrogating the harmful effects of AGEs. RAGE-/- animals appeared to be protected from the additional harmful effects of a high AGE containing diet suggesting the central role of RAGE in progression of NASH. Increased cell proliferation and oxidative stress in isolated primary Kupffer cells with the addition of AGEs suggests they are an important mechanism in which AGEs contribute to liver injury.
Publish Date 2016-09-14 19:04
Citation Leung C, Herath CB, Jia Z, Andrikopoulos S, Brown BE, Davies MJ, Rivera LR, Furness JB, Forbes JM, Angus PW. Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease. World J Gastroenterol 2016; 22(35): 8026-8040
URL http://www.wjgnet.com/1007-9327/full/v22/i35/8026.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i35.8026
Full Article (PDF) WJG-22-8026.pdf
Full Article (Word) WJG-22-8026.doc
Manuscript File 27036-Review.docx
Answering Reviewers 27036-Answering reviewers.pdf
Audio Core Tip 27036-Audio core tip.mp3
Biostatistics Review Certificate 27036-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 27036-Conflict-of-interest statement.pdf
Copyright License Agreement 27036-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 27036-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 27036-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 27036-Institutional review board statement.pdf
Supplementary Material 27036-Supplementary material.pdf
Peer-review Report 27036-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27036-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27036-Scientific misconduct check.pdf
Scientific Editor Work List 27036-Scientific editor work list.pdf