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11/3/2016 3:50:00 PM | Browse: 257 | Download: 412
Publication Name World Journal of Hematology
Manuscript ID 27052
Country of Manuscript Source United States
Received
2016-05-08 14:42
Peer-Review Started
2016-05-09 19:27
To Make the First Decision
2016-06-06 11:04
Return for Revision
2016-06-13 14:49
Revised
2016-06-14 04:59
Second Decision
2016-08-01 09:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-15 10:20
Articles in Press
2016-08-15 10:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-31 16:09
Publish the Manuscript Online
2016-11-03 15:47
ISSN 2218-6204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Hematology
Manuscript Type Basic Study
Article Title Identifying changes in punitive transcriptional factor binding sites from regulatory single nucleotide polymorphisms that are significantly associated with disease or sickness
Manuscript Source Invited Manuscript
All Author List Norman E Buroker
Funding Agency and Grant Number
Corresponding author Norman E Buroker, PhD, Department of Pediatrics, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, United States. nburoker@u.washington.edu
Keywords Regulatory single nucleotide polymorphisms; Alleles; Transcriptional factors; Transcriptional factor binding sites; Linkage disequilibrium; Disease or sickness
Core Tip Disease or trait-predisposing single nucleotide polymorphisms (SNPs) in or near genes can alter the transcriptional factor binding sites (TFBS) for the TFs regulating the gene; thereby affecting the health of an individual. In this report, the disease or sickness associated regulatory SNPs (rSNPs) within a sampling of nine human genes were studied with respect to the alterations in TFBS. From this sampling there were 73 punitive unique TFBS generated by the common rSNP alleles compared to 124 generated by the minor alleles indicating the tremendous diversity of potential TFs that are capable of affecting the health of person.
Publish Date 2016-11-03 15:47
Citation Buroker NE. Identifying changes in punitive transcriptional factor binding sites from regulatory single nucleotide polymorphisms that are significantly associated with disease or sickness. World J Hematol 2016; 5(4): 75-87
Url http://www.wjgnet.com/2218-6204/full/v5/i4/75.htm
DOI http://dx.doi.org/10.5315/wjh.v5.i4.75
Full Article (PDF) WJH-5-75.pdf
Full Article (Word) WJH-5-75.doc
Manuscript File 27052-Review.docx
Answering Reviewers 27052-Answering reviewers.pdf
Audio Core Tip 27052-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 27052-Conflict-of-interest statement.pdf
Copyright License Agreement 27052-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 27052-Institutional review board statement.pdf
Peer-review Report 27052-Peer-review(s).pdf
Scientific Misconduct Check 27052-Scientific misconduct check.pdf
Scientific Editor Work List 27052-Scientific editor work list.pdf