| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ryul Kim, Bhumsuk Keam, Dohee Kwon, Chan-Young Ock, Miso Kim, Tae Min Kim, Hak Jae Kim, Yoon Kyung Jeon, In Kyu Park, Chang Hyun Kang, Dong-Wan Kim, Young Tae Kim and Dae Seog Heo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Seoul National University Hospital Research Fund |
03-2015-0380 |
| Ministry of Health and Welfare, South Korea |
HI06C0874 |
|
| Corresponding Author |
Bhumsuk Keam, MD, PhD, Clinical Associate Professor, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, South Korea. bhumsuk@snu.ac.kr
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| Key Words |
Esophageal neoplasm; Programmed death ligand-1 protein; c-Met protein; Prognosis; p16INK4A protein |
| Core Tip |
The clinical significance of expression of programmed death ligand-1 (PD-L1) in esophageal squamous cell carcinoma (ESCC) has not yet been fully established. We analyzed tissue microarrays of surgical specimen of 200 ESCC patients by immunohistochemistry with antibodies directed against PD-L1, p16, and c-Met. Our results suggest that tumors from approximately one-third of the ESCC patients are positive for PD-L1 expression, and PD-L1 expression is positively correlated with c-Met expression. Although PD-L1 positivity was not found to be associated with survival of ESCC patients, we show that it may play a critical role in distant failure and progression of ESCC.
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| Publish Date |
2016-09-30 18:06 |
| Citation |
Kim R, Keam B, Kwon D, Ock CY, Kim M, Kim TM, Kim HJ, Jeon YK, Park IK, Kang CH, Kim DW, Kim YT, Heo DS. Programmed death ligand-1 expression and its prognostic role in esophageal squamous cell carcinoma. World J Gastroenterol 2016; 22(37): 8389-8397 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i37/8389.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i37.8389 |
