Publication Name	World Journal of Gastroenterology
Manuscript ID	27652
Country	Taiwan

Received	2016-06-10 15:08
Peer-Review Started	2016-06-14 18:56
To Make the First Decision	2016-07-12 16:12
Return for Revision	2016-07-14 17:38
Revised	2016-07-24 15:31
Second Decision	2016-08-01 19:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-08-08 17:34
Articles in Press	2016-08-08 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-26 15:07
Publish the Manuscript Online	2016-09-14 19:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Different pre-S deletion patterns and their association with hepatitis B virus genotypes
Manuscript Source	Invited Manuscript
All Author List	Bing-Fang Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Science Council, Taiwan NSC 96-2320-B-030-004-MY3
Corresponding Author	Bing-Fang Chen, PhD, Professor of School of Medicine, Fu Jen Catholic University, 510 Chung-Cheng Road, Hsin-Chuang Dist, New Taipei City 24205, Taiwan. nurs1018@mail.fju.edu.tw
Key Words	Hepatitis B virus; Pre-S deletion; Chronic hepatitis; Hepatocellular carcinoma; Genotype; Liver cirrhosis
Core Tip	This is a comprehensive study of the influence of HBV genotypes B (HBV/B) and C (HBV/C) on the emergence of different types of pre-S deletions. Different patterns of pre-S deletion were found in HBV/B and HBV/C. Deletion in the pS2-B1 epitope, nucleocapsid binding site, start codon of M, and site for viral secretion was frequently found in HBV/B. Conversely, deletion in pS2-T and the start codon of L was frequently found in HBV/C. The prevalence of different pre-S deletions differed between HBV/B and HBV/C among patients with liver disease.
Publish Date	2016-09-14 19:04
Citation	Chen BF. Different pre-S deletion patterns and their association with hepatitis B virus genotypes. World J Gastroenterol 2016; 22(35): 8041-8049
URL	http://www.wjgnet.com/1007-9327/full/v22/i35/8041.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i35.8041

Full Article (PDF)	WJG-22-8041.pdf
Full Article (Word)	WJG-22-8041.doc
Manuscript File	27652-Review.doc
Answering Reviewers	27652-Answering reviewers.pdf
Audio Core Tip	27652-Audio core tip.mp3
Biostatistics Review Certificate	27652-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	27652-Conflict-of-interest statement.pdf
Copyright License Agreement	27652-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	27652-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	27652-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27652-Language certificate.pdf
Supplementary Material	27652-Supplementary material.pdf
Peer-review Report	27652-Peer-review(s).pdf
Scientific Misconduct Check	27652-Scientific misconduct check.pdf
Scientific Editor Work List	27652-Scientific editor work list.pdf