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9/15/2014 8:54:00 PM | Browse: 615 | Download: 258
Publication Name World Journal of Gastroenterology
Manuscript ID 2772
Country/Territory China
Received
2013-03-13 10:36
Peer-Review Started
2013-03-13 21:01
To Make the First Decision
2013-04-03 09:21
Return for Revision
2013-04-11 16:15
Revised
2013-05-02 21:43
Second Decision
2013-06-19 12:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-06-20 00:57
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-07-25 11:22
Publish the Manuscript Online
2013-08-13 11:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury
Manuscript Source Invited Manuscript
All Author List Qi Yang, Feng-Ping Zheng, Ya-Shi Zhan, Jin Tao, Si-Wei Tan, Hui-Ling Liu and Bin Wu
Funding Agency and Grant Number
Funding Agency Grant Number
Grants-in-Aid from the Major Projects Incubator Program of the National Key Basic Research Program of China 2012CB526700
National Natural Science Foundation of China 30971357
Natural Science Foundation of Guangdong Province S2011020002348
Science and Technology Planning Project of Guangdong Province 2009B060300001
Major Projects Incubator Program of Sun Yat-Sen University 10ykjc25
Corresponding Author Bin Wu, MD, PhD, Professor, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. binwu001@hotmail.com
Key Words Tumor necrosis factor-α; Intestine; Mucosa; Apoptosis; c-Jun N-terminal kinase
Core Tip Ischemia-reperfusion (I/R) injury is a critical physiopathological phenomenon wherein further damage may occur when the blood supply of ischemic organs is recovered, and the mechanism of I/R remains unclear. This paper demonstrates that tumor necrosis factor-α (TNF-α) played a pivotal role in intestinal I/R injury, and pretreatment with the TNF-α inhibitor pentoxifylline or the TNF-α antibody infliximab remarkably attenuated I/R-induced injury by inhibiting TNF-α-mediated apoptosis and c-Jun N-terminal kinase (JNK) activation. The results of the study indicate there is a TNF-α-mediated JNK activation response to intestinal I/R injury.
Publish Date 2013-08-13 11:13
Citation Yang Q, Zheng FP, Zhan YS, Tao J, Tan SW, Liu HL, Wu B. Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury. World J Gastroenterol 2013; 19(30): 4925-4934
URL http://www.wjgnet.com/1007-9327/full/v19/i30/4925.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i30.4925
Full Article (PDF) WJG-19-4925.pdf
Manuscript File Yang Qi-WJG-Revised.doc
Answering Reviewers Format for Answering Reviewers.doc
Copyright License Agreement BPG Copyright Assignment-Yang Q.pdf