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10/25/2016 4:05:00 PM | Browse: 845 | Download: 1051
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 27816
Country United States
Received
2016-06-17 08:47
Peer-Review Started
2016-06-18 12:13
To Make the First Decision
2016-07-27 08:25
Return for Revision
2016-07-29 12:03
Revised
2016-07-30 08:11
Second Decision
2016-08-19 12:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-29 11:28
Articles in Press
2016-08-29 11:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-19 08:43
Publish the Manuscript Online
2016-10-25 16:05
ISSN 1948-9366 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Minireviews
Article Title Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies
Manuscript Source Invited Manuscript
All Author List Santosh Shenoy
Funding Agency and Grant Number
Corresponding Author Santosh Shenoy, MD, FACS, Department of Surgery, KCVA and University of Missouri Kansas City, 4801 E Linwood Blvd, Kansas City, MO 64128, United States. shenoy2009@hotmail.com
Key Words Goblet cell carcinoid of the appendix; Notch-1 signaling; Immunomarkers; Math-1 signaling; Intestinal stem cells; Disease management
Core Tip Goblet cell carcinoids tumors are a distinctive group of heterogeneous appendiceal neoplasm that exhibit unique clinical and pathologic features. The pathogenesis is unclear however the tumor likely arises from pluripotent intestinal epithelial crypt base stem cells. Loss of Notch signaling may be the driver mutation with other successive downstream mutations likely favors them into progressing and behavior similar to poorly differentiated adenocarcinoma with minimal neuroendocrine differentiation. Surgery remains the main treatment modality. We discuss the clinical implications of this cancer focusing on the tumor biology, mutations, signaling mechanisms and management.
Publish Date 2016-10-25 16:05
Citation Shenoy S. Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies. World J Gastrointest Surg 2016; 8(10): 660-669
URL http://www.wjgnet.com/1948-9366/full/v8/i10/660.htm
DOI http://dx.doi.org/10.4240/wjgs.v8.i10.660
Full Article (PDF) WJGS-8-660.pdf
Full Article (Word) WJGS-8-660.doc
Manuscript File 27816-Review.docx
Answering Reviewers 27816-Answering reviewers.pdf
Audio Core Tip 27816-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 27816-Conflict-of-interest statement.pdf
Copyright License Agreement 27816-Copyright assignment.pdf
Peer-review Report 27816-Peer-review(s).pdf
Scientific Misconduct Check 27816-Scientific misconduct check.pdf
Scientific Editor Work List 27816-Scientific editor work list.pdf