Publication Name	World Journal of Gastroenterology
Manuscript ID	27825
Country	Germany

Received	2016-06-20 16:39
Peer-Review Started	2016-06-21 12:12
To Make the First Decision	2016-07-12 15:49
Return for Revision	2016-07-15 09:13
Revised	2016-08-01 15:22
Second Decision	2016-09-21 15:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-09-28 18:51
Articles in Press	2016-09-28 18:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-26 09:18
Publish the Manuscript Online	2016-11-06 15:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	First-line endoscopic treatment with over-the-scope clips significantly improves the primary failure and rebleeding rates in high-risk gastrointestinal bleeding: A single-center experience with 100 cases
Manuscript Source	Invited Manuscript
All Author List	Hans-Jürgen Richter-Schrag, Torben Glatz, Christine Walker, Andreas Fischer and Robert Thimme
Funding Agency and Grant Number
Corresponding Author	Hans-Jürgen Richter-Schrag, MD, Professor of Medicine, Center of Interdisciplinary Gastrointestinal Endoscopy, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Street 55, D-79106 Freiburg, Germany. hans-juergen.schrag@uniklinik-freiburg.de
Key Words	Gastrointestinal bleeding; Rockall risk score; Over-the-scope clip; First-line endoscopic treatment; Second-line endoscopic treatment
Core Tip	In the present study, the over-the-scope clip (OTSC) was evaluated for first-line and second-line endoscopic treatment (FLET, SLET) of high-risk upper and lower gastrointestinal bleeding. One hundred OTSCs were applied in 93 patients. Primary hemostasis and clinical success was achieved in 88% and 78%, respectively. Statistical analysis shows no significant influence of anticoagulants on the rebleeding rate. The total mortality was 21.5%. Primary failure was significantly reduced by the use of OTSC as FLET (4.9% vs 23.1%, p = 0.008). This largest single-center data of OTSC-placement in high-risk GI bleeding published to date shows, for the first time, that FLET is a significant predictor of reduced rebleeding (OR = 5.2; p = 0.009).
Publish Date	2016-11-06 15:43
Citation	Richter-Schrag HJ, Glatz T, Walker C, Fischer A, Thimme R. First-line endoscopic treatment with over-the-scope clips significantly improves the primary failure and rebleeding rates in high-risk gastrointestinal bleeding: A single-center experience with 100 cases. World J Gastroenterol 2016; 22(41): 9162-9171
URL	http://www.wjgnet.com/1007-9327/full/v22/i41/9162.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i41.9162

Full Article (PDF)	WJG-22-9162.pdf
Full Article (Word)	WJG-22-9162.doc
Manuscript File	27825-Review.docx
Answering Reviewers	27825-Answering reviewers.pdf
Audio Core Tip	27825-Audio core tip.m4a
Biostatistics Review Certificate	27825-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	27825-Conflict-of-interest statement.pdf
Copyright License Agreement	27825-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160618003224.docx
Institutional Review Board Approval Form or Document	27825-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27825-Language certificate.pdf
Peer-review Report	27825-Peer-review(s).pdf
Scientific Misconduct Check	27825-Scientific misconduct check.pdf
Scientific Editor Work List	27825-Scientific editor work list.pdf