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10/12/2016 2:18:00 PM | Browse: 535 | Download: 637
Publication Name World Journal of Gastroenterology
Manuscript ID 27894
Country/Territory Italy
Received
2016-06-21 09:49
Peer-Review Started
2016-06-22 13:06
To Make the First Decision
2016-07-13 13:31
Return for Revision
2016-07-18 10:02
Revised
2016-08-06 15:35
Second Decision
2016-08-10 17:53
Accepted by Journal Editor-in-Chief
2016-08-12 00:04
Accepted by Company Editor-in-Chief
2016-08-23 17:30
Articles in Press
2016-08-23 17:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-21 18:42
Publish the Manuscript Online
2016-10-12 14:18
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Infectious Diseases
Manuscript Type Basic Study
Article Title TM6SF2 E167K variant predicts severe liver fibrosis for human immunodeficiency/hepatitis C virus co-infected patients, and severe steatosis only for a non-3 hepatitis C virus genotype
Manuscript Source Invited Manuscript
All Author List Caterina Sagnelli, Marco Merli, Caterina Uberti-Foppa, Hamid Hasson, Anna Grandone, Grazia Cirillo, Stefania Salpietro, Carmine Minichini, Mario Starace, Emanuela Messina, Patrizia Morelli, Emanuele Miraglia Del Giudice, Adriano Lazzarin, Nicola Coppola and Evangelista Sagnelli
Funding Agency and Grant Number
Corresponding Author Dr. Evangelista Sagnelli, Professor, Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Via L. Armanni 5, 80131 Naples, Italy. evangelistasagnelli@libero.it
Key Words Human immunodeficiency virus/hepatitis C virus co-infection; TM6SF2; Liver histology; Liver steatosis; Liver biopsy
Core Tip The transmembrane 6 superfamily member 2 (TM6SF2) E167K variant has been identified as an independent predictor of severe liver steatosis in patients with hepatitis C virus (HCV)-related chronic hepatitis (CH) lacking human immunodeficiency virus (HIV) infection. We analyzed the impact of the TM6SF2 E167K variant on the liver histology of 167 HIV/HCV co-infected patients with CH. The TM6SF2 E167K variant was found to be an independent predictor of severe fibrosis, while an independent association with severe steatosis was demonstrated only for patients with a non-3 HCV genotype.
Publish Date 2016-10-12 14:18
Citation Sagnelli C, Merli M, Uberti-Foppa C, Hasson H, Grandone A, Cirillo G, Salpietro S, Minichini C, Starace M, Messina E, Morelli P, Miraglia Del Giudice E, Lazzarin A, Coppola N, Sagnelli E. TM6SF2 E167K variant predicts severe liver fibrosis for human immunodeficiency/hepatitis C virus co-infected patients, and severe steatosis only for a non-3 hepatitis C virus genotype. World J Gastroenterol 2016; 22(38): 8509-8518
URL http://www.wjgnet.com/1007-9327/full/v22/i38/8509.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i38.8509
Full Article (PDF) WJG-22-8509.pdf
Full Article (Word) WJG-22-8509.doc
Manuscript File 27894-Review.doc
Answering Reviewers 27894-Answering reviewers.pdf
Audio Core Tip 27894-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 27894-Conflict-of-interest statement.pdf
Copyright License Agreement 27894-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 27894-Language certificate.pdf
Peer-review Report 27894-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27894-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27894-Scientific misconduct check.pdf
Scientific Editor Work List 27894-Scientific editor work list.pdf