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12/19/2016 8:28:00 PM | Browse: 1051 | Download: 2310
Publication Name World Journal of Gastroenterology
Manuscript ID 27954
Country Hungary
Received
2016-06-23 09:10
Peer-Review Started
2016-06-24 12:42
To Make the First Decision
2016-08-22 15:10
Return for Revision
2016-08-23 08:40
Revised
2016-09-20 14:19
Second Decision
2016-11-01 08:11
Accepted by Journal Editor-in-Chief
2016-11-01 16:12
Accepted by Company Editor-in-Chief
2016-11-16 14:21
Articles in Press
2016-11-13 15:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-13 17:56
Publish the Manuscript Online
2016-12-19 20:29
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma
Manuscript Source Invited Manuscript
All Author List Orsolya Galamb, Alexandra Kalmár, Barbara Kinga Barták, Árpád V Patai, Katalin Leiszter, Bálint Péterfia, Barnabás Wichmann, Gábor Valcz, Gábor Veres, Zsolt Tulassay and Béla Molnár
Funding Agency and Grant Number
Funding Agency Grant Number
National Research, Development and Innovation Office KMR-12-1-2012-0216
Hungarian Scientific Research Fund OTKA-K111743
Corresponding Author Orsolya Galamb, PhD, 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi str 46, H-1088 Budapest, Hungary. orsg1@yahoo.com
Key Words DNA methylation; Aging; Colorectal cancer; Adenoma; Epigenetic drift; Epigenetic clock; Secreted frizzled related protein 1
Core Tip Several age-related DNA methylation altera-tions could be observed during colorectal cancer (CRC) formation and progression affecting the mRNA expression of certain CRC- and adenoma-related key control genes such as hypermethylated secreted frizzled related protein 1 (SFRP1), spectrin repeat containing nuclear envelope protein 1 and hypomethylated cell migration-inducing protein. For the first time significantly lower SFRP1 methylation levels were demonstrated in colonic tissue from children (under 18 years) compared to healthy adults. The main CRC-associated signal transduction pathways, such as WNT signaling and PI3K/Akt pathways are also influenced during aging.
Publish Date 2016-12-19 20:29
Citation Galamb O, Kalmár A, Barták BK, Patai ÁV, Leiszter K, Péterfia B, Wichmann B, Valcz G, Veres G, Tulassay Z, Molnár B. Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. World J Gastroenterol 2016; 22(47): 10325-10340
URL http://www.wjgnet.com/1007-9327/full/v22/i47/10325.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i47.10325
Full Article (PDF) WJG-22-10325.pdf
Full Article (Word) WJG-22-10325.doc
Manuscript File 27954-Review.doc
Answering Reviewers 27954-Answering reviewers.pdf
Audio Core Tip 27954-Audio core tip.mp3
Biostatistics Review Certificate 27954-Biostatistics statement.PDF
Copyright License Agreement 27954-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160622170138.doc
Institutional Review Board Approval Form or Document 27954-Institutional review board statement.pdf
Supplementary Material 27954-Supplementary materials.pdf
Peer-review Report 27954-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27954-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27954-Scientific misconduct check.pdf
Scientific Editor Work List 27954-Scientific editor work list.pdf