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Articles Published Processes
10/12/2016 2:18:00 PM | Browse: 937 | Download: 1525
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Received |
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2016-06-24 08:54 |
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Peer-Review Started |
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2016-06-24 15:29 |
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To Make the First Decision |
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2016-08-22 15:09 |
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Return for Revision |
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2016-08-23 08:50 |
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Revised |
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2016-08-27 07:35 |
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Second Decision |
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2016-09-02 18:04 |
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Accepted by Journal Editor-in-Chief |
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2016-09-02 18:22 |
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Accepted by Company Editor-in-Chief |
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2016-09-08 13:20 |
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Articles in Press |
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2016-09-08 13:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-09-27 19:32 |
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Publish the Manuscript Online |
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2016-10-12 14:18 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Natalia A Osna, Dan Feng, Murali Ganesan, Priya F Maillacheruvu, David J Orlicky, Samuel W French, Dean J Tuma and Kusum K Kharbanda |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Veterans Affairs, Office of Research and Development (Biomedical Laboratory Research and Development) |
BX001155 (to Kharbanda KK) |
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| Corresponding Author |
Kusum K Kharbanda, PhD, Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service (151), 4101 Woolworth Avenue, Omaha, NE 68105, United States. kkharbanda@unmc.edu |
| Key Words |
Methyl balance; S-adenosylmethionine; S-adenosylhomocysteine; Guanidinoacetate; Alcohol |
| Core Tip |
We examined the role of a combined exposure to ethanol and guanidinoacetate (GAA) in the patho?genesis of liver injury. Exposure to either treatment lowers the hepatic methylation index which is defined as the ratio of the methyl donor, S-adenosylmethionine to its product S-adenosylhomocysteine. We observed a worsening of liver pathology with prolonged GAA and ethanol treatment compared to either treatment alone. These detrimental consequences were related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol. |
| Publish Date |
2016-10-12 14:18 |
| Citation |
Osna NA, Feng D, Ganesan M, Maillacheruvu PF, Orlicky DJ, French SW, Tuma DJ, Kharbanda KK. Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury. World J Gastroenterol 2016; 22(38): 8497-8508 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i38/8497.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i38.8497 |
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