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11/8/2016 8:12:00 PM | Browse: 751 | Download: 989
Publication Name World Journal of Virology
Manuscript ID 28019
Country/Territory India
Received
2016-06-26 17:06
Peer-Review Started
2016-06-27 17:25
To Make the First Decision
2016-08-04 16:03
Return for Revision
2016-08-05 09:01
Revised
2016-08-09 00:00
Second Decision
2016-08-19 09:17
Accepted by Journal Editor-in-Chief
2016-08-21 21:49
Accepted by Company Editor-in-Chief
2016-08-29 11:51
Articles in Press
2016-08-29 11:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-31 15:21
Publish the Manuscript Online
2016-11-08 20:12
ISSN 2220-3249 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Basic Study
Article Title Role of RNA secondary structure in emergence of compartment specific hepatitis B virus immune escape variants
Manuscript Source Invited Manuscript
All Author List Sibnarayan Datta and Runu Chakravarty
Funding Agency and Grant Number
Funding Agency Grant Number
University Grants Commission (UGC), Min. of Human Resource and Development, Govt. of India and Defence Research to Sibnarayan Datta
Indian Council of Medical Research (ICMR), Ministry of Health and Family Welfare (MoHFW) to Runu Chakravarty
Development Organization (DRDO), Min. of Defence, Govt. of India to Sibnarayan Datta
Corresponding Author Sibnarayan Datta, PhD, Molecular Virology Laboratory, Defence Research, Laboratory (DRDO), Tezpur 784001, Assam, India. sndatta1978@gmail.com
Key Words Hepatitis B; Compartmentalization; Peripheral blood leukocytes; pgRNA; RNA secondary structure; G145R
Core Tip We have previously shown that, in our study population, distribution of hepatitis B virus (HBV) sub-genotypes A1 and A2 is highly biased in the serum/plasma and peripheral blood leukocyte (PBL) com-partments respectively. Analysing the predicted base pairing patterns of pregenomic RNAs (pgRNAs), specific for HBV subgenotype A1 and A2, we demonstrate that the potent immune escape mutation G145R evolves specifically in the context of HBV subgenotype A2. The PBL compartment is exposed to strong anti-HBs immunity, and thus G145R is highly advantageous for the virus to persist. This explains the exclusive pre-ponderance of subgenotype A2 in the PBL com-partment, sharply contrasting the prevalence of sub-genotype A1 in the serum/plasma.
Publish Date 2016-11-08 20:12
Citation Datta S, Chakravarty R. Role of RNA secondary structure in emergence of compartment specific hepatitis B virus immune escape variants. World J Virol 2016; 5(4): 161-169
URL http://www.wjgnet.com/2220-3249/full/v5/i4/161.htm
DOI http://dx.doi.org/10.5501/wjv.v5.i4.161
Full Article (PDF) WJV-5-161.pdf
Full Article (Word) WJV-5-161.doc
Manuscript File 28019-Review.docx
Answering Reviewers 28019-Answering reviewers.pdf
Audio Core Tip 28019-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 28019-Conflict-of-interest statement.pdf
Copyright License Agreement 28019-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28019-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 28019-Language certificate.pdf
Scientific Research Process 28019-Scientific research process.pdf
Peer-review Report 28019-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 28019-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 28019-Scientific misconduct check.pdf
Scientific Editor Work List 28019-Scientific editor work list.pdf