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1/6/2017 8:51:00 AM | Browse: 771 | Download: 1147
Publication Name World Journal of Hepatology
Manuscript ID 28328
Country/Territory France
2016-06-29 16:57
Peer-Review Started
2016-06-30 08:39
To Make the First Decision
2016-08-10 14:54
Return for Revision
2016-08-11 10:01
2016-09-10 18:37
Second Decision
2016-10-13 12:15
Accepted by Journal Editor-in-Chief
2016-10-14 12:32
Accepted by Company Editor-in-Chief
2016-11-02 10:54
Articles in Press
2016-11-02 11:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-23 13:57
Publish the Manuscript Online
2017-01-06 08:51
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Review
Article Title PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis
Manuscript Source Invited Manuscript
All Author List Aline Awad and Ama Gassama-Diagne
Funding Agency and Grant Number
Funding Agency Grant Number
Agence Nationale de Recherche sur le Sida et les hépatites (ANRS, France), Ligue contre le cancer, France
Corresponding Author Ama Gassama-Diagne, MD, Inserm Unité 1193, Hôpital Paul Brousse, 12 Avenue Paul Vaillant Couturier, 94800 Villejuif, France. ama.gassama@inserm.fr
Key Words Hepatitis C virus; Phosphoinositide 3-kinase; SH2-containing inositol polyphosphate 5-phosphatase; Epithelial cell polarity; Phosphoinositides
Core Tip Chronic hepatitis C virus (HCV) infection leads to liver cirrhosis and cancer. HCV infection modulates the lipid metabolism. Phosphoinositides are minor pho-spholipids that are also modified by HCV infec-tion. phosph-atidylinositol (PtdIns)(3,4,5)P3 is mainly formed by phosphoinositide 3-kinase (PI3K), and can be dephosphorylated by SH2-containing inositol polyphosphate 5-phosphatase (SHIP2) to generate PtdIns(3,4)P2. In this review, we will discuss the effects of SHIP2 and PI3K on the formation of cell polarity and how their expression and activation are modulated by HCV infection, leading to the disruption of cell polarity. This pathway is also discussed in the event of insulin resistance and nonalcoholic fatty liver disease related to HCV infection.
Publish Date 2017-01-06 08:51
Citation Awad A, Gassama-Diagne A. PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis. World J Hepatol 2017; 9(1): 18-29
Url http://www.wjgnet.com/1948-5182/full/v9/i1/18.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i1.18
Full Article (PDF) WJH-9-18.pdf
Full Article (Word) WJH-9-18.doc
Manuscript File 28328-Review.doc
Answering Reviewers 28328-Answering reviewers.pdf
Audio Core Tip 28328-Audio core tip.mp3
Copyright License Agreement 28328-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28328-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 28328-Language certificate.pdf
Peer-review Report 28328-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 28328-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 28328-Scientific misconduct check.pdf
Scientific Editor Work List 28328-Scientific editor work list.pdf