| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zeljko Djakovic, Ivka Djakovic, Vedran Cesarec, Goran Madzarac, Tomislav Becejac, Goran Zukanovic, Domagoj Drmic, Lovorka Batelja, Anita Zenko Sever, Danijela Kolenc, Alen Pajtak, Nikica Knez, Mladen Japjec, Kresimir Luetic, Dinko Stancic-Rokotov, Sven Seiwerth and Predrag Sikiric |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Science, Education and Sports, Republic of Croatia |
108-1083570-3635 |
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| Corresponding Author |
Predrag Sikiric, MD, PhD, Professor, Departments of Pharmacology and Pathology Medical Faculty University of Zagreb, Salata 11, POB 916, 10000 Zagreb,
Croatia. sikiric@mef.hr
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| Key Words |
Esophagogastric anastomosis; L-NAME; Aggravation; BPC 157; L-arginine; Curative treatment; Rats |
| Core Tip |
In rats underwent esophagogastric anas-tomosis, BPC 157 (given intraperitoneally or in drinking water) fully counteracted an otherwise serious disease course since very beginning (i.e., with BPC 157 bath blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment, along with L-NAME, nullified any effect of L-NAME that otherwise intensi-fied the regular course. Consistently, with worsening (with L-NAME administration) and amelioration (with L-arginine), either L-arginine-amelioration prevails (i.e., esophageal and gastric lesions are attenuated) or they counteract each other (L-NAME + L-arginine), an effect which is further reversed toward a marked beneficial effect with the addition of BPC 157 (L-NAME + L-arginine + BPC 157).
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| Publish Date |
2016-11-06 15:43 |
| Citation |
Djakovic Z, Djakovic I, Cesarec V, Madzarac G, Becejac T, Zukanovic G, Drmic D, Batelja L, Zenko Sever A, Kolenc D, Pajtak A, Knez N, Japjec M, Luetic K, Stancic-Rokotov D, Seiwerth S, Sikiric P. Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME. World J Gastroenterol 2016; 22(41): 9127-9140 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i41/9127.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i41.9127 |
