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Publication Name World Journal of Gastroenterology
Manuscript ID 2901
Country/Territory South Korea
Received
2013-03-23 22:51
Peer-Review Started
2013-03-24 18:39
To Make the First Decision
2013-04-16 08:59
Return for Revision
2013-04-17 10:46
Revised
2013-05-15 17:41
Second Decision
2013-06-03 16:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-06-04 09:51
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-07-24 21:04
Publish the Manuscript Online
2013-08-06 09:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Nutrition & Dietetics
Manuscript Type Autobiography
Article Title Garcinia Cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation
Manuscript Source Invited Manuscript
All Author List Young-Je Kim, Myung-Sook Choi, Yong Bok Park, Sang Ryong Kim, Mi-Kyung Lee and Un Ju Jung
Funding Agency and Grant Number
Funding Agency Grant Number
Basic Science Research Program 2011-0022387
SRC program, Center for Food and Nutritional Genomics from National Research Foundation of Korea funded by the Ministry of Education, Science and Technology 2012-0000644
Corresponding Author Un Ju Jung, PhD, Center for Food and Nutritional Genomics Research, Kyungpook National University, 1370 San-Kyuk Dong, Puk-Ku, Daegu 702-701, South Korea. jungunju@naver.com
Key Words Garcinia Cambogia; Anti-adiposity; Metabolic changes; Hepatic collagen accumulation; Hepatic inflammation; Hepatic oxidative stress
Core Tip Garcinia Cambogia (GC) is a popular dietary supplement for weight loss. However, little is known about the efficacy and hepatotoxicity of long-term GC supplementation in mice fed a high-fat diet (HFD). We observed that GC ameliorated HFD-induced adiposity by modulating enzymatic activity and gene expression involved in fatty acid metabolism. GC also reduced the plasma resistin level and glucose intolerance. However, GC caused hepatic collagen accumulation, inflammation and oxidative stress without affecting hepatic steatosis.
Publish Date 2013-08-06 09:19
Citation Kim YJ, Choi MS, Park YB, Kim SR, Lee MK, Jung UJ. Garcinia Cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation. World J Gastroenterol 2013; 19(29): 4689-4701
URL http://www.wjgnet.com/1007-9327/full/v19/i29/4689.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i29.4689
Full Article (PDF) WJG-19-4689.pdf
Manuscript File 2901-Review.doc
Answering Reviewers 2901-Answering reviewers.pdf
Copyright License Agreement 2901-Copyright assignment.pdf
Institutional Review Board Approval Form or Document ethics committee approval document.doc
Non-Native Speakers of English Editing Certificate 2901-Language certificate.pdf
Peer-review Report 2901-Peer reviews.pdf
Scientific Editor Work List 2901-Scientific editor work list.doc