| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Impact of high dose vitamin C on platelet function
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Bassem M Mohammed, Kimberly W Sanford, Bernard J Fisher, Erika J Martin, Daniel Contaifer Jr, Urszula Osinska Warncke, Dayanjan S Wijesinghe, Charles E Chalfant, Donald F Brophy, Alpha A Fowler Ⅲ and Ramesh Natarajan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Virginia Blood Foundation |
No. 11 (To KS and RN) |
| Department of Veterans Affairs (Merit Review Award) |
No. 5I01BX001792 (To CEC) |
| National Institutes of Health |
No. 1S10OD010641 (To CEC) |
| National Institutes of Health |
No. 5R01HL125353 (To CEC) |
| VCU Massey Cancer Center with funding from National Institutes of Health |
No. P30CA016059 |
|
| Corresponding Author |
Ramesh Natarajan, PhD, Professor of Medicine, Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980050, Richmond, VA 23298,
United States. ramesh.natarajan@vcuhealth.org |
| Key Words |
Platelet function; Thromboelastography; Flow cytometry; Platelet lipidomics; Vitamin C |
| Core Tip |
High dose intravenous vitamin C (VitC) is often used by Complementary and Alternate Medicine practitioners for a variety of ailments. Moreover, use of high dose VitC by mainstream physicians as an adjunct in the treatment of sepsis, sepsis induced acute lung injury, cancer and burns is on the rise. However, there is no information on the impact of these high doses VitC on normal platelet (PLT) function. Prolonged exposure of ex vivo PLTs to high doses of VitC altered some PLT functions as assessed by thromboelastography. How-ever, short term exposure (< 8 d) or low dose exposure had almost no impact on PLT function.
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| Publish Date |
2017-01-22 18:57 |
| Citation |
Mohammed BM, Sanford KW, Fisher BJ, Martin EJ, Contaifer Jr D, Warncke UO, Wijesinghe DS, Chalfant CE, Brophy DF, Fowler Ⅲ AA, Natarajan R. Impact of high dose vitamin C on platelet function. World J Crit Care Med 2017; 6(1): 37-47 |
| URL |
http://www.wjgnet.com/2220-3141/full/v6/i1/37.htm |
| DOI |
http://dx.doi.org/10.5492/wjccm.v6.i1.37 |
