Publication Name	World Journal of Gastroenterology
Manuscript ID	29075
Country	Germany

Received	2016-07-28 10:03
Peer-Review Started	2016-08-01 17:54
To Make the First Decision	2016-09-28 08:37
Return for Revision	2016-09-30 10:41
Revised	2016-10-10 05:00
Second Decision	2016-11-17 16:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-11-28 17:48
Articles in Press	2016-11-28 17:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-18 21:11
Publish the Manuscript Online	2016-12-26 19:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Field of Vision
Article Title	Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis
Manuscript Source	Invited Manuscript
All Author List	Sebastian Mueller
Funding Agency and Grant Number
Corresponding Author	Sebastian Mueller, MD, PhD, Professor of Medicine, Vice Head, Co-Director, Department of Medicine and Center for Alcohol Research, Salem Medical Center, University of Heidelberg, Zeppelinstraße 11 - 33, 69121 Heidelberg, Germany. sebastian.mueller@urz.uni-heidelberg.de
Key Words	Liver stiffness; Stretch force; Sinusoidal pressure hypothesis; Liver cirrhosis; Hepatic arterial buffer response; Biomechanics; Arterialization; Hepatic stellate cells; Fibroblasts; Cellular and intercellular mechano-signaling
Core Tip	This paper introduces the sinusoidal pressure hypothesis, which identifies an elevation of sinusoidal pressure (SP) as cause of fibrosis/cirrhosis. Accordingly, elevated SP is the major upstream event that initiates fibrosis progression via biomechanic signaling by stretching of perisinusoidal cells. Fibrosis progression is determined by the degree and time of elevated SP. The cirrhotic extracellular matrix eventually matches the degree of pressure. Arterialization of the stiff cirrhotic liver represents the final self-perpetuating key event exposing the low-pressure-organ to pathologically high pressures. It also defines the “point of no return” where fibrosis progression becomes irreversible.
Publish Date	2016-12-26 19:13
Citation	Mueller S. Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis. World J Gastroenterol 2016; 22(48): 10482-10501
URL	http://www.wjgnet.com/1007-9327/full/v22/i48/10482.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i48.10482

Full Article (PDF)	WJG-22-10482.pdf
Full Article (Word)	WJG-22-10482.doc
Manuscript File	29075-Review.docx
Answering Reviewers	29075-Answering reviewers.pdf
Audio Core Tip	29075-Audio core tip.wav
Conflict-of-Interest Disclosure Form	29075-Conflict-of-interest statement.pdf
Copyright License Agreement	29075-Copyright assignment.pdf
Supplementary Material	29075-Supplementary material.pdf
Peer-review Report	29075-Peer-review(s).pdf
Scientific Misconduct Check	29075-Scientific misconduct check.pdf
Scientific Editor Work List	29075-Scientific editor work list.pdf