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12/26/2016 7:12:00 PM | Browse: 1117 | Download: 1139
Publication Name World Journal of Gastroenterology
Manuscript ID 29075
Country/Territory Germany
2016-07-28 10:03
Peer-Review Started
2016-08-01 17:54
To Make the First Decision
2016-09-28 08:37
Return for Revision
2016-09-30 10:41
2016-10-10 05:00
Second Decision
2016-11-17 16:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-11-28 17:48
Articles in Press
2016-11-28 17:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-18 21:11
Publish the Manuscript Online
2016-12-26 19:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Field of Vision
Article Title Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis
Manuscript Source Invited Manuscript
All Author List Sebastian Mueller
Funding Agency and Grant Number
Corresponding Author Sebastian Mueller, MD, PhD, Professor of Medicine, Vice Head, Co-Director, Department of Medicine and Center for Alcohol Research, Salem Medical Center, University of Heidelberg, Zeppelinstraße 11 - 33, 69121 Heidelberg, Germany. sebastian.mueller@urz.uni-heidelberg.de
Key Words Liver stiffness; Stretch force; Sinusoidal pressure hypothesis; Liver cirrhosis; Hepatic arterial buffer response; Biomechanics; Arterialization; Hepatic stellate cells; Fibroblasts; Cellular and intercellular mechano-signaling
Core Tip This paper introduces the sinusoidal pressure hypothesis, which identifies an elevation of sinusoidal pressure (SP) as cause of fibrosis/cirrhosis. Accordingly, elevated SP is the major upstream event that initiates fibrosis progression via biomechanic signaling by stretching of perisinusoidal cells. Fibrosis progression is determined by the degree and time of elevated SP. The cirrhotic extracellular matrix eventually matches the degree of pressure. Arterialization of the stiff cirrhotic liver represents the final self-perpetuating key event exposing the low-pressure-organ to pathologically high pressures. It also defines the “point of no return” where fibrosis progression becomes irreversible.
Publish Date 2016-12-26 19:13
Citation Mueller S. Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis. World J Gastroenterol 2016; 22(48): 10482-10501
URL http://www.wjgnet.com/1007-9327/full/v22/i48/10482.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i48.10482
Full Article (PDF) WJG-22-10482.pdf
Full Article (Word) WJG-22-10482.doc
Manuscript File 29075-Review.docx
Answering Reviewers 29075-Answering reviewers.pdf
Audio Core Tip 29075-Audio core tip.wav
Conflict-of-Interest Disclosure Form 29075-Conflict-of-interest statement.pdf
Copyright License Agreement 29075-Copyright assignment.pdf
Supplementary Material 29075-Supplementary material.pdf
Peer-review Report 29075-Peer-review(s).pdf
Scientific Misconduct Check 29075-Scientific misconduct check.pdf
Scientific Editor Work List 29075-Scientific editor work list.pdf