Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	29589
Country	United States

Received	2016-08-21 19:35
Peer-Review Started	2016-08-23 15:53
To Make the First Decision	2016-09-26 10:32
Return for Revision	2016-09-28 10:18
Revised	2016-10-08 06:50
Second Decision	2016-10-10 09:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-10-24 14:59
Articles in Press	2016-10-24 14:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-09 11:15
Publish the Manuscript Online	2016-11-21 07:50

ISSN	2220-3176 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	Leptospirosis: A clinical review of evidence based diagnosis, treatment and prevention
Manuscript Source	Invited Manuscript
All Author List	Alison B Lane and Michael M Dore
Funding Agency and Grant Number
Corresponding Author	Michael M Dore, MD, Department of Medicine, Naval Hospital Guam, PSC 4555 Box 208, FPO AP 96540, Guam, CA 96910, United States. michael.m.dore.mil@mail.mil
Key Words	Leptospirosis; Tropical diseases; Infectious disease
Core Tip	Leptospirosis is a zoonotic disease with world?wide distribution and increasing prevalence. Infection is caused by the spirochete Leptospira, with common exposure being contaminated fresh water. Most infections are asymptomatic, but symptoms range from a mild, self-limiting, non-specific febrile illness to fulminant respiratory and renal failure with a high mortality rate. Typical treatment for mild cases is oral doxycycline, though azithromycin and oral penicillins are reasonable alternatives. Intravenous penicillin G has long been the standard of care for severe cases though limited studies show no benefit compared to third generation cephalosporins. We review the clinical presentation, diagnosis, and treatment of leptospirosis.
Publish Date	2016-11-21 07:50
Citation	Lane AB, Dore MM. Leptospirosis: A clinical review of evidence based diagnosis, treatment and prevention. World J Clin Infect Dis 2016; 6(4): 61-66
URL	http://www.wjgnet.com/2220-3176/full/v6/i4/61.htm
DOI	http://dx.doi.org/10.5495/wjcid.v6.i4.61

Full Article (PDF)	WJCID-6-61.pdf
Full Article (Word)	WJCID-6-61.doc
Manuscript File	29589-Review.docx
Answering Reviewers	29589-Answering reviewers.pdf
Audio Core Tip	29589-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29589-Conflict-of-interest statement.pdf
Copyright License Agreement	29589-Copyright assignment.pdf
Peer-review Report	29589-Peer-review(s).pdf
Scientific Misconduct Check	29589-Scientific misconduct check.pdf
Scientific Editor Work List	29589-Scientific editor work list.pdf