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1/16/2017 10:39:00 AM | Browse: 322 | Download: 297
Publication Name World Journal of Hepatology
Manuscript ID 29788
Country of Manuscript Source Brazil
Received
2016-08-27 21:00
Peer-Review Started
2016-08-29 16:21
To Make the First Decision
2016-09-27 17:26
Return for Revision
2016-10-08 21:25
Revised
2016-10-18 05:10
Second Decision
2016-11-11 17:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-11-22 15:21
Articles in Press
2016-11-22 15:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-01-09 08:32
Publish the Manuscript Online
2017-01-16 10:39
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Endocrinology and Metabolism
Manuscript Type Editorial
Article Title Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade
Manuscript Source Invited Manuscript
All Author List Vanessa Souza-Mello
Funding Agency and Grant Number
Corresponding author Vanessa Souza-Mello, RD, PhD, Biomedical Centre, Institute of Biology, Department of Anatomy, State University of Rio de Janeiro, Av. 28 de Setembro 87, Fundos, Vila Isabel, Rio de Janeiro 20551-030, Brazil. souzamello.uerj@gmail.com
Keywords Non-alcoholic fatty liver disease; Insulin resistance; Angiotensin receptor blockers; MAS receptor; Renin-angiotensin system
Core Tip Intrahepatic renin-angiotensin system activation contributes to insulin resistance and non-alcoholic fatty liver disease onset. ANG Ⅱ interaction with angiotensin Ⅱ receptor type 1 (AT1R) mediates pro-inflammatory and pro-fibrogenic responses, besides enhancing the oxidative stress, which makes the liver more prone to noxious liver diseases. AT1R blockers mitigate insulin resistance and fatty liver by enhancing beta-oxidation, reducing lipogenesis and controlling inflammation. The impact of the AT1R blockade on liver ACE2-angiotensin (1-7)-MAS receptor axis remains to be fully unraveled.
Publish Date 2017-01-16 10:39
Citation Souza-Mello V. Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade. World J Hepatol 2017; 9(2): 74-79
Url http://www.wjgnet.com/1948-5182/full/v9/i2/74.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i2.74
Full Article (PDF) WJH-9-74.pdf
Full Article (Word) WJH-9-74.doc
Manuscript File 29788-Review.docx
Answering Reviewers 29788-Answering reviewers.pdf
Audio Core Tip 29788-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 29788-Conflict-of-interest statement.pdf
Copyright License Agreement 29788-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 29788-Language certificate.pdf
Peer-review Report 29788-Peer-review(s).pdf
Scientific Misconduct Check 29788-Scientific misconduct check.pdf
Scientific Editor Work List 29788-Scientific editor work list.pdf