Publication Name	World Journal of Hepatology
Manuscript ID	29788
Country	Brazil

Received	2016-08-27 21:00
Peer-Review Started	2016-08-29 16:21
To Make the First Decision	2016-09-27 17:26
Return for Revision	2016-10-08 21:25
Revised	2016-10-18 05:10
Second Decision	2016-11-11 17:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-11-22 15:21
Articles in Press	2016-11-22 15:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-09 08:32
Publish the Manuscript Online	2017-01-16 10:39

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Editorial
Article Title	Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade
Manuscript Source	Invited Manuscript
All Author List	Vanessa Souza-Mello
Funding Agency and Grant Number
Corresponding Author	Vanessa Souza-Mello, RD, PhD, Biomedical Centre, Institute of Biology, Department of Anatomy, State University of Rio de Janeiro, Av. 28 de Setembro 87, Fundos, Vila Isabel, Rio de Janeiro 20551-030, Brazil. souzamello.uerj@gmail.com
Key Words	Non-alcoholic fatty liver disease; Insulin resistance; Angiotensin receptor blockers; MAS receptor; Renin-angiotensin system
Core Tip	Intrahepatic renin-angiotensin system activation contributes to insulin resistance and non-alcoholic fatty liver disease onset. ANG Ⅱ interaction with angiotensin Ⅱ receptor type 1 (AT1R) mediates pro-inflammatory and pro-fibrogenic responses, besides enhancing the oxidative stress, which makes the liver more prone to noxious liver diseases. AT1R blockers mitigate insulin resistance and fatty liver by enhancing beta-oxidation, reducing lipogenesis and controlling inflammation. The impact of the AT1R blockade on liver ACE2-angiotensin (1-7)-MAS receptor axis remains to be fully unraveled.
Publish Date	2017-01-16 10:39
Citation	Souza-Mello V. Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade. World J Hepatol 2017; 9(2): 74-79
URL	http://www.wjgnet.com/1948-5182/full/v9/i2/74.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i2.74

Full Article (PDF)	WJH-9-74.pdf
Full Article (Word)	WJH-9-74.doc
Manuscript File	29788-Review.docx
Answering Reviewers	29788-Answering reviewers.pdf
Audio Core Tip	29788-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29788-Conflict-of-interest statement.pdf
Copyright License Agreement	29788-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	29788-Language certificate.pdf
Peer-review Report	29788-Peer-review(s).pdf
Scientific Misconduct Check	29788-Scientific misconduct check.pdf
Scientific Editor Work List	29788-Scientific editor work list.pdf