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Articles Published Processes
1/19/2017 11:16:00 AM | Browse: 926 | Download: 1524
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Received |
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2016-09-12 08:59 |
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Peer-Review Started |
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2016-09-12 16:15 |
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To Make the First Decision |
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2016-11-09 08:30 |
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Return for Revision |
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2016-11-09 10:38 |
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Revised |
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2016-11-19 11:31 |
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Second Decision |
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2016-12-02 08:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-12-08 16:14 |
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Articles in Press |
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2016-12-08 16:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-12-29 04:18 |
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Typeset the Manuscript |
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2017-01-08 18:56 |
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Publish the Manuscript Online |
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2017-01-19 11:16 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
You Lv, Tao Ye, Hui-Peng Wang, Jia-Ying Zhao, Wen-Jie Chen, Xin Wang, Chen-Xia Shen, Yi-Bin Wu and Yuan-Kun Cai |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Project of Shanghai Health and Family Planning |
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| Commission and the 5th People’s Hospital of Shanghai, Fudan University under grant |
201440505 |
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| Corresponding Author |
Yuan-Kun Cai, MD, Associate Professor, Chief Surgeon of General Surgery, Department of General Surgery, The 5th People’s Hospital of Shanghai, Fudan University, 801 Heqing Road, Shanghai 200240,
China. 18918168583@163.com
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| Key Words |
Colorectal neoplasms; Bacteroides fragilis toxin; Fragilysin; Recombinant proteins; Mice |
| Core Tip |
Bacteroides fragilis enterotoxin-2 (BFT-2) has been considered to promote the development of colorectal cancer (CRC). In this study, we obtained the biologically active recombinant BFT-2 in vitro and found that lower-dose of biologically active BFT-2 could inhibit colorectal tumor formation via the route of intra-gastric administration in a mice model of CRC, which manifested to inhibit cell proliferation and promoted apoptosis. The specific mechanism is still unknown but the findings provide some insights into prevention and treatment of CRC as an intestinal mucosal vaccine.
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| Publish Date |
2017-01-19 11:16 |
| Citation |
Lv Y, Ye T, Wang HP, Zhao JY, Chen WJ, Wang X, Shen CX, Wu YB, Cai YK. Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo. World J Gastroenterol 2017; 23(4): 603-613 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i4/603.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i4.603 |
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