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9/16/2014 11:44:00 AM | Browse: 952 | Download: 778
Publication Name World Journal of Gastroenterology
Manuscript ID 3013
Country/Territory Denmark
Received
2013-04-02 11:16
Peer-Review Started
2013-04-02 20:31
To Make the First Decision
2013-04-22 10:02
Return for Revision
2013-04-22 10:15
Revised
2013-05-03 21:40
Second Decision
2013-05-07 17:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-05-08 09:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-05-09 10:33
Publish the Manuscript Online
2013-05-14 16:05
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Field of Vision
Article Title Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett's esophagus
Manuscript Source Invited Manuscript
All Author List Jingbo Zhao and Hans Gregersen
Funding Agency and Grant Number
Corresponding Author Jingbo Zhao, MD, PhD, Mech-Sense, Department of Gastroenterology and Surgery, Aalborg University Hospital, Sdr. Skovvej 15, DK-9000 Aalborg, Denmark. jz@rn.dk
Key Words Esophagus; Intestinal metaplasia; Caudal-related homeodomain transcription factors; Apical sodium-dependent bile acid transporter; Aberrant expression
Core Tip Aberrant co-expression of Caudal-related homeodomain transcription factors (CDXs) and apical sodium-dependent bile acid transporter (ASBT) in the epithelium of Barrett's esophagus (BE) indicates association among these factors. Acid and bile re铿倁x induce CDXs gene expression and can lead to formation of BE. CDX-mediated promoter activation can lead to aberrant expression of ASBT. The BE phenotype may be better than squamous epithelium to protect against refluxed acid and bile. On the other hand the BE phenotype is associated with increased risk of esophageal adenocarcinoma (EAC). Furthermore, the decreased expressions of CDXs and ASBT in high-grade esophageal dysplasia indicate that CDXs and ASBT are inhibitory factors to the progression of EAC.
Publish Date 2013-05-14 16:05
Citation Zhao J, Gregersen H. Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett’s esophagus. World J Gastroenterol 2013; 19(18): 2736-2739
URL http://www.wjgnet.com/1007-9327/full/v19/i18/2736.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i18.2736
Full Article (PDF) WJG-19-2736.pdf
Manuscript File 3013-Review.doc
Answering Reviewers 3013-Answering reviewers.pdf
Copyright License Agreement 3013-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 3013-Language certificate.pdf
Peer-review Report 3013-Peer reviews.pdf
Scientific Editor Work List 3013-Scientific editor work list.doc