Publication Name	World Journal of Nephrology
Manuscript ID	30231
Country	United States

Received	2016-09-20 17:36
Peer-Review Started	2016-09-24 20:59
To Make the First Decision	2016-10-20 08:45
Return for Revision	2016-11-14 11:38
Revised	2016-11-18 03:06
Second Decision	2016-12-14 18:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-12-28 15:37
Articles in Press	2016-12-28 15:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-01 20:29
Publish the Manuscript Online	2017-03-05 19:09

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Editorial
Article Title	Application of established pathophysiologic processes brings greater clarity to diagnosis and treatment of hyponatremia
Manuscript Source	Invited Manuscript
All Author List	John K Maesaka, Louis J Imbriano and Nobuyuki Miyawaki
Funding Agency and Grant Number
Corresponding Author	John K Maesaka, MD, Department of Medicine and Division of Nephrology and Hypertension, Winthrop-University Hospital, 200 Old Country Road, Suite 135, Mineola, NY 11501, United States. jmaesaka@winthrop.org
Key Words	Hyponatremia; cerebral-renal salt wasting; fractional excretion of urate
Core Tip	When dealing with normo-volemic, non-edematous hyponatremic patients the initial treatment should be i.v. normal saline, combined with measuring the fractional excretion of urate. As serum sodium is corrected, the patients with syndrome of inappropriate antidiuresis (SIAD) will normalize the fractional excretion of urate, while patients with cerebral-renal salt wasting will have a persistently elevated fractional excretion of urate. It appears that patients with SIAD will have a slow or no increase in serum sodium with saline, while patients with renal salt wasting will have a more rapid increase in serum sodium.
Publish Date	2017-03-05 19:09
Citation	Maesaka JK, Imbriano LJ, Miyawaki N. Application of established pathophysiologic processes brings greater clarity to diagnosis and treatment of hyponatremia. World J Nephrol 2017; 6(2): 59-71
URL	http://www.wjgnet.com/2220-6124/full/v6/i2/59.htm
DOI	http://dx.doi.org/10.5527/wjn.v6.i2.59

Full Article (PDF)	WJN-6-59.pdf
Full Article (Word)	WJN-6-59.doc
Manuscript File	30231-Review.doc
Answering Reviewers	30231-Answering reviewers.pdf
Audio Core Tip	30231-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30231-Conflict-of-interest statement.pdf
Copyright License Agreement	30231-Copyright assignment.pdf
Peer-review Report	30231-Peer-review(s).pdf
Scientific Misconduct Check	30231-Scientific misconduct check.pdf
Scientific Editor Work List	30231-Scientific editor work list.pdf