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3/28/2017 10:34:00 AM | Browse: 944 | Download: 1130
Publication Name World Journal of Gastroenterology
Manuscript ID 30328
Country/Territory Belgium
Received
2016-09-27 09:32
Peer-Review Started
2016-09-28 14:32
To Make the First Decision
2016-12-19 11:29
Return for Revision
2016-12-19 16:26
Revised
2017-01-20 22:26
Second Decision
2017-03-01 11:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-02 17:09
Articles in Press
2017-03-02 17:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-03-15 16:11
Publish the Manuscript Online
2017-03-28 10:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Regulation of intestinal permeability: The role of proteases
Manuscript Source Invited Manuscript
All Author List Hanne Van Spaendonk, Hannah Ceuleers, Leonie Witters, Eveline Patteet, Jurgen Joossens, Koen Augustyns, Anne-Marie Lambeir, Ingrid De Meester, Joris G De Man and Benedicte Y De Winter
Funding Agency and Grant Number
Funding Agency Grant Number
University of Antwerp grant GOA 2013
Corresponding Author Benedicte Y De Winter, Professor, MD, PhD, Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. benedicte.dewinter@uantwerpen.be
Key Words Intestinal permeability; Intestinal barrier; Tight junction; Paracellular permeability; Proteases; Proteinase-activated receptor; Protease inhibitor; Antiproteases
Core Tip Increased intestinal permeability is a novel player in the pathophysiology of various intestinal and extra-intestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. A dysregulated protease/antiproteases balance is suggested as a cause of intestinal barrier dysfunction, with a subsequent increase in permeability. Immune cells infiltrating in the lamina propria during inflammatory conditions provide a pro-inflammatory environment by the production of cytokines and proteases. Protease inhibition has therapeutic potential but more research is needed to elucidate the exact involvement of specific proteases in gut physiology and intestinal barrier function.
Publish Date 2017-03-28 10:34
Citation Van Spaendonk H, Ceuleers H, Witters L, Patteet E, Joossens J, Augustyns K, Lambeir AM, De Meester I, De Man JG, De Winter BY. Regulation of intestinal permeability: The role of proteases. World J Gastroenterol 2017; 23(12): 2106-2123
URL http://www.wjgnet.com/1007-9327/full/v23/i12/2106.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i12.2106
Full Article (PDF) WJG-23-2106.pdf
Full Article (Word) WJG-23-2106.doc
Manuscript File 30328-Review.docx
Answering Reviewers 30328-Answering reviewers.pdf
Audio Core Tip 30328-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 30328-Conflict-of-interest statement.pdf
Copyright License Agreement 30328-Copyright assignment.pdf
Peer-review Report 30328-Peer-review(s).pdf
Scientific Misconduct Check 30328-Scientific misconduct check.pdf
Scientific Editor Work List 30328-Scientific editor work list.pdf