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3/13/2017 7:05:00 PM | Browse: 1024 | Download: 3493
Publication Name World Journal of Gastroenterology
Manuscript ID 30376
Country/Territory China
Received
2016-09-29 16:42
Peer-Review Started
2016-10-01 14:19
To Make the First Decision
2016-12-02 08:34
Return for Revision
2016-12-06 17:02
Revised
2016-12-21 11:26
Second Decision
2017-02-06 14:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-08 10:47
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-02-25 11:08
Typeset the Manuscript
2017-03-06 16:27
Publish the Manuscript Online
2017-03-13 19:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathway
Manuscript Source Unsolicited Manuscript
All Author List Chen Sun, Fu-Jing Wang, Hao-Gang Zhang, Xun-Zheng Xu, Rui-Chun Jia, Lei Yao and Peng-Fei Qiao
Funding Agency and Grant Number
Funding Agency Grant Number
Science Foundation of Education Department of Heilongjiang Province, China 12541430
Corresponding Author Dr. Peng-Fei Qiao, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China. lunwenqpf@126.com
Key Words miR-34a; Oxaliplatin; Colorectal cancer; Macroautophagy; Transforming growth factor-β/Smad pathway
Core Tip This study demonstrated a significant association between microRNA (miR)-34a expression and the acquired chemoresistance to oxaliplatin (OXA) in colorectal cancer (CRC). miR-34a mediates OXA resistance through its inhibitory effects on macroautophagy by the transforming growth factor (TGF)-β/Smad4 pathway. Our findings suggest that miR-34a is a potential therapeutic target for improving the chemotherapeutic effect of OXA in CRC.
Publish Date 2017-03-13 19:06
Citation Sun C, Wang FJ, Zhang HG, Xu XZ, Jia RC, Yao L, Qiao PF. miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathway. World J Gastroenterol 2017; 23(10): 1816-1827
URL http://www.wjgnet.com/1007-9327/full/v23/i10/1816.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i10.1816
Full Article (PDF) WJG-23-1816.pdf
Full Article (Word) WJG-23-1816.doc
Manuscript File 30376-Review.doc
Answering Reviewers 30376-Answering reviewers.pdf
Audio Core Tip 30376-Audio core tip.WAV
Biostatistics Review Certificate 30376-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 30376-Conflict-of-interest statement.pdf
Copyright License Agreement 30376-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 30376-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160929162549.docx
Institutional Review Board Approval Form or Document 30376-Institutional review board statement.pdf
Supplementary Material 30376-Supplementary material.pdf
Peer-review Report 30376-Peer-review(s).pdf
Scientific Misconduct Check 30376-Scientific misconduct check.pdf
Scientific Editor Work List 30376-Scientific editor work list.pdf