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Publication Name World Journal of Hepatology
Manuscript ID 3061
Country Denmark
Received
2013-04-05 10:52
Peer-Review Started
2013-04-06 16:30
To Make the First Decision
2013-05-14 18:43
Return for Revision
2013-05-17 15:34
Revised
2013-06-08 06:05
Second Decision
2013-08-20 10:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-08-20 12:38
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-09-03 08:32
Publish the Manuscript Online
2013-10-01 17:51
ISSN 1948-5182 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia
Manuscript Source Invited Manuscript
All Author List Rikke Hebo Larsen, Mette S Kjær, Martin Eefsen, Fin Stolze Larsen and Peter Nissen Bjerring
Funding Agency and Grant Number
Corresponding Author Peter Nissen Bjerring, PhD, Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark. peterbjerring@gmail.com
Key Words Brain oedema; Acute liver failure; Neuroprotection; Hyperammonaemia; Ciclosporin
Core Tip Acute liver failure and hyperammonaemia can lead to severe brain oedema. Preserving mitochondrial function by treatment with ciclosporin has shown potential in in vitro studies. In this study we evaluated the effect of ciclosporin in a rat model of acute hyperammonaemia on intracranial pressure, brain water content and expression of the water channel aquaporin-4. We did not find a beneficial effect of ciclosporin on intracranial pressure, brain water content or aquaporin-4 expression.
Publish Date 2013-10-01 17:51
Citation Larsen RH, Kj?r MS, Eefsen M, Larsen FS, Bjerring PN. Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia. World J Hepatol 2013; 5(9): 513-520
URL http://www.wjgnet.com/1948-5182/full/v5/i9/513.htm
DOI http://dx.doi.org/10.4254/wjh.v5.i9.513
Full Article (PDF) WJH-5-513.pdf
Manuscript File 3061-Review.doc
Answering Reviewers 3061-Answering reviewers.pdf
Copyright License Agreement 3061-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 3061-Language certificate.pdf
Peer-review Report 3061-Peer reviews.pdf
Scientific Editor Work List 3061-Scientific editor work list.doc