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3/13/2017 1:20:00 PM | Browse: 327 | Download: 380
Publication Name World Journal of Hepatology
Manuscript ID 30675
Country of Manuscript Source Germany
Received
2016-10-13 16:08
Peer-Review Started
2016-10-17 10:32
To Make the First Decision
2016-11-10 08:40
Return for Revision
2016-11-14 15:18
Revised
2016-11-24 01:38
Second Decision
2016-12-06 11:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-12-14 17:00
Articles in Press
2016-12-14 17:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-03-07 10:19
Publish the Manuscript Online
2017-03-13 13:20
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Biochemistry and Molecular Biology
Manuscript Type Meta-Analysis
Article Title Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Wasco Wruck and James Adjaye
Funding Agency and Grant Number
Funding Agency Grant Number
The medical faculty of the Heinrich Heine University Düsseldorf
Corresponding author James Adjaye, PhD, Professor, Medical Faculty, Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany. james.adjaye@med.uni-duesseldorf.de
Keywords Non-alcoholic fatty liver disease; Alcoholic liver disease cholesterol; Bile; Alcohol dehydrogenase; CYP7A1
Core Tip With a meta-analysis of newly published liver biopsy-derived transcriptome datasets we identified multiple key genes and pathways in common and mutually exclusive in alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). We provide a compendium of comparative regulation for all KEGG pathways in both diseases and propose a list of biomarkers distinguishing both diseases. One surprising finding was that chole-sterol metabolism was up-regulated in NAFLD and down-regulated in ALD although leading to the same steatosis phenotype which might be explained by an insufficient conversion rate to bile acids under both conditions.
Publish Date 2017-03-13 13:20
Citation Wruck W, Adjaye J. Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease. World J Hepatol 2017; 9(8): 443-454
Url http://www.wjgnet.com/1948-5182/full/v9/i8/443.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i8.443
Full Article (PDF) WJH-9-443.pdf
Full Article (Word) WJH-9-443.doc
Manuscript File 30675-Review.doc
Answering Reviewers 30675-Answering reviewers.pdf
Audio Core Tip 30675-Audio core tip.mp3
Biostatistics Review Certificate 30675-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 30675-Conflict-of-interest statement.pdf
Copyright License Agreement 30675-Copyright assignment.pdf
Data Sharing Statement 30675-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 30675-Grant application form(s).pdf
Supplementary Material Supplementary_Material_20161012002429.doc
Peer-review Report 30675-Peer-review(s).pdf
Scientific Misconduct Check 30675-Scientific misconduct check.pdf
Scientific Editor Work List 30675-Scientific editor work list.pdf