Publication Name	World Journal of Gastroenterology
Manuscript ID	30908
Country	Italy

Received	2016-10-23 17:18
Peer-Review Started	2016-10-25 09:00
To Make the First Decision	2016-12-19 11:29
Return for Revision	2016-12-20 11:03
Revised	2016-12-29 22:56
Second Decision	2017-01-16 13:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-01-17 17:00
Articles in Press	2017-01-17 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-14 16:25
Publish the Manuscript Online	2017-02-26 18:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Retrospective Study
Article Title	Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?
Manuscript Source	Invited Manuscript
All Author List	Luca Reggiani Bonetti, Simona Lionti, Federica Domati and Valeria Barresi
Funding Agency and Grant Number
Corresponding Author	Dr. Valeria Barresi, Department of Pathology in Evolutive Age and Adulthood, “Gaetano Barresi”, University of Messina, Via Consolare Valeria, 98125 Messina, Italy. vbarresi@unime.it
Key Words	Rectal carcinoma; Dworak; Acellular mucin pools; Downstaging; Mucinous
Core Tip	This study evaluates the prognostic signi-ficance of clinico-pathological variables in patients with locally advanced rectal carcinoma treated with neo-adjuvant chemo-radiotherapy (CRT) and surgery. Our data show that tumors with cN+ status, extensive/lower involvement of the rectum, mucinous histotype and poor differentiation have a lower response to pre-operative CRT. Dworak tumor regression grade was prognostically informative; however, a simplified two-tiered system was more reproducible and prognostically significant. Acellular mucin pools were found in a percentage of cases with excellent outcomes. Although acellular mucin pools should be considered as complete pathological responses, careful histological examination is mandatory to exclude residual mucinous carcinoma.
Publish Date	2017-02-26 18:20
Citation	Reggiani Bonetti L, Lionti S, Domati F, Barresi V. Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery? World J Gastroenterol 2017; 23(8): 1412-1423
URL	http://www.wjgnet.com/1007-9327/full/v23/i8/1412.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i8.1412

Full Article (PDF)	WJG-23-1412.pdf
Full Article (Word)	WJG-23-1412.doc
Manuscript File	30908-Review.doc
Answering Reviewers	30908-Answering reviewers.pdf
Audio Core Tip	30908-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30908-Conflict-of-interest statement.pdf
Copyright License Agreement	30908-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	30908-Language certificate.pdf
Peer-review Report	30908-Peer-review(s).pdf
Scientific Misconduct Check	30908-Scientific misconduct check.pdf
Scientific Editor Work List	30908-Scientific editor work list.pdf