Publication Name	World Journal of Gastroenterology
Manuscript ID	31407
Country	Mexico

Received	2016-11-15 08:57
Peer-Review Started	2016-11-15 16:48
To Make the First Decision	2017-01-10 16:00
Return for Revision	2017-01-12 09:01
Revised	2017-01-21 01:21
Second Decision	2017-02-15 19:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-02-17 10:26
Articles in Press	2017-02-17 10:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-27 20:27
Publish the Manuscript Online	2017-03-06 13:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Review
Article Title	Current knowledge on the laboratory diagnosis of Clostridium difficile infection
Manuscript Source	Invited Manuscript
All Author List	Adrián Martínez-Meléndez, Adrián Camacho-Ortiz, Rayo Morfin-Otero, Héctor Jesús Maldonado-Garza, Licet Villarreal-Treviño and Elvira Garza-González
Funding Agency and Grant Number
Corresponding Author	Elvira Garza-González, PhD, Servicio de Gastroenterología, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León. Av. Francisco I. Madero Pte. S/N, Col. Mitras Centro. Monterrey, Nuevo Leon 64460, Mexico. elvira_garza_gzz@yahoo.com
Key Words	Clostridium difficile; Toxigenic culture; Nucleic acid amplification tests; Enzyme immunoassay; Diagnosis; Glutamate dehydrogenase
Core Tip	This work is a review of the strategies that may be used for laboratory diagnosis of infection with Clostridium difficile. First, we provide general recommendations for testing of samples taking in account the guidelines of the Society for Healthcare Epidemiology of America/Infectious Diseases Society of America and the American College of Gastroenterology. We reviewed diverse methods of diagnosis including, culture, toxigenic culture, cell cytotoxic neutralization assay and the use of enzyme immuno assays. Finally, we present an overview of singleplex and multiplex nucleic acid amplification tests.
Publish Date	2017-03-06 13:24
Citation	Martínez-Meléndez A, Camacho-Ortiz A, Morfin-Otero R, Maldonado-Garza HJ, Villarreal-Treviño L, Garza-González E. Current knowledge on the laboratory diagnosis of Clostridium difficile infection. World J Gastroenterol 2017; 23(9): 1552-1567
URL	http://www.wjgnet.com/1007-9327/full/v23/i9/1552.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i9.1552

Full Article (PDF)	WJG-23-1552.pdf
Full Article (Word)	WJG-23-1552.doc
Manuscript File	31407-Review.docx
Answering Reviewers	31407-Answering reviewers.pdf
Audio Core Tip	31407-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31407-Conflict-of-interest statement.pdf
Copyright License Agreement	31407-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	31407-Language certificate.pdf
Peer-review Report	31407-Peer-review(s).pdf
Scientific Misconduct Check	31407-Scientific misconduct check.pdf
Scientific Editor Work List	31407-Scientific editor work list.pdf