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6/20/2017 12:12:52 PM | Browse: 948 | Download: 1478
Publication Name World Journal of Gastroenterology
Manuscript ID 31466
Country/Territory United States
Received
2016-11-18 09:21
Peer-Review Started
2016-11-21 16:15
To Make the First Decision
2017-01-19 13:54
Return for Revision
2017-01-20 14:53
Revised
2017-02-04 05:48
Second Decision
2017-04-11 15:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-04-13 11:02
Articles in Press
2017-04-13 11:02
Publication Fee Transferred
2017-05-26 08:54
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-12 09:25
Publish the Manuscript Online
2017-06-20 12:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research & Experimental Medicine
Manuscript Type Basic Study
Article Title Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicapoc, in non-alcoholic liver disease
Manuscript Source Unsolicited Manuscript
All Author List Latha Paka, David E Smith, Dawoon Jung, Siobhan McCormack, Ping Zhou, Bin Duan, Jing-Song Li, Jiaqi Shi, Yong-Jie Hao, Kai Jiang, Michael Yamin, Itzhak D Goldberg and Prakash Narayan
Funding Agency and Grant Number
Corresponding Author Latha Paka, PhD, Senior Research Scientist, Department of Research and Development, Angion Biomedica Corp., 51 Charles Lindbergh Blvd, Uniondale, NY 11553, United States. spaka@angion.com
Key Words High fat diet; Liver; Steatosis; Fibrosis; KCa3.1 channel; Senicapoc; Inflammation
Core Tip Given the large numbers of people with fatty livers and even relatively indolent steatosis can result in a significant population progressing to non-alcoholic steatohepatitis (NASH), NASH with fibrosis and cirrhosis. We report for the first time that a KCa3.1 channel inhibitor exerts an anti-steatotic effect in the setting of fatty liver disease which can be harnessed for the treatment of liver fibrosis. Second, we are the first to report that Senicapoc, a drug that has been through Phase Ⅲ clinical trials, can be repurposed for the treatment of fatty liver disease and potentially for the treatment of other lipid disorders.
Publish Date 2017-06-20 12:12
Citation Paka L, Smith DE, Jung D, McCormack S, Zhou P, Duan B, Li JS, Shi J, Hao YJ, Jiang K, Yamin M, Goldberg ID, Narayan P. Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicapoc, in non-alcoholic liver disease. World J Gastroenterol 2017; 23(23): 4181-4190
URL http://www.wjgnet.com/1007-9327/full/v23/i23/4181.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i23.4181
Full Article (PDF) WJG-23-4181.pdf
Full Article (Word) WJG-23-4181.doc
Manuscript File 31466-Review.docx
Answering Reviewers 31466-Answering reviewers.pdf
Audio Core Tip 31466-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 31466-Conflict-of-interest statement.pdf
Copyright License Agreement 31466-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 31466-Institutional animal care and use committee statement.pdf
Peer-review Report 31466-Peer-review(s).pdf
Scientific Misconduct Check 31466-Scientific misconduct check.pdf
Scientific Editor Work List 31466-Scientific editor work list.pdf