Publication Name	World Journal of Gastroenterology
Manuscript ID	31503
Country	United States

Received	2016-11-21 08:52
Peer-Review Started	2016-11-23 11:46
To Make the First Decision	2016-12-19 09:53
Return for Revision	2016-12-24 18:40
Revised	2017-01-06 05:17
Second Decision	2017-03-01 11:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-03-02 16:55
Articles in Press	2017-03-02 16:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-08 09:37
Publish the Manuscript Online	2017-03-19 18:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis
Manuscript Source	Invited Manuscript
All Author List	Animesh Jain, Evan J Lipson, William H Sharfman, Steven R Brant and Mark G Lazarev
Funding Agency and Grant Number
Corresponding Author	Animesh Jain, MD, Division of Gastro¬enterology and Hepatology, Department of Internal Medicine, University of North Carolina Chapel Hill, 130 Mason Farm Road, Campus Box 7080, Chapel Hill, NC 27599-7080, United States. animeshj@med.unc.edu
Key Words	Ipilimumab; Melanoma; Enterocolitis; Colitis; Infliximab; Corticosteroid; Colonic ulcer
Core Tip	Immune-mediated enterocolitis is a common toxicity of ipilimumab therapy for melanoma. Infliximab is often needed as a second line therapy in steroid refractory cases. Our findings suggest that colonic ulcers seen on lower gastrointestinal endoscopy may predict a steroid refractory disease course. This would support a role for endoscopy in select cases, and suggest that early initiation of infliximab therapy may be appropriate in patients with colonic ulceration. These results require further exploration in larger patient cohorts.
Publish Date	2017-03-19 18:45
Citation	Jain A, Lipson EJ, Sharfman WH, Brant SR, Lazarev MG. Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis. World J Gastroenterol 2017; 23(11): 2023-2028
URL	http://www.wjgnet.com/1007-9327/full/v23/i11/2023.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i11.2023

Full Article (PDF)	WJG-23-2023.pdf
Full Article (Word)	WJG-23-2023.doc
Manuscript File	31503-Review.docx
Answering Reviewers	31503-Answering reviewers.pdf
Audio Core Tip	31503-Audio core tip.mp3
Biostatistics Review Certificate	31503-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31503-Conflict-of-interest statement.pdf
Copyright License Agreement	31503-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20161121035554.docx
Institutional Review Board Approval Form or Document	31503-Institutional review board statement.pdf
Supplementary Material	Supplementary_Material_20161121035117.pdf
Peer-review Report	31503-Peer-review(s).pdf
Scientific Misconduct Check	31503-Scientific misconduct check.pdf
Scientific Editor Work List	31503-Scientific editor work list.pdf