| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Allergy |
| Manuscript Type |
Basic Study |
| Article Title |
Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and b-lactoglobulin-induced intestinal food allergy mouse models
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Yun Liu, Zhen-Yu Yang, Wen-Kui Dai, Jian-Qiong Huang, Yin-Hu Li, Juan Zhang, Chuang-Zhao Qiu, Chun Wei, Qian Zhou, Xin Sun, Xin Feng, Dong-Fang Li, He-Ping Wang and Yue-Jie Zheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Innovation of Science and Technology Commission of Shenzhen Municipality |
JCYJ20120828092009036 |
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| Corresponding Author |
Dr. Yue-Jie Zheng, Director, Department of Respiratory, Shenzhen Children’s Hospital, No. 7019 Yitian Road, Shenzhen 518026,
China. shine1990@sina.com
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| Key Words |
Bifidobacterium infantis; Asthma; Allergy; Ovalbumin; b-lactoglobulin |
| Core Tip |
Bifidobacterium infantis CGMCC313-2 significantly decreased the serum concentration of IgE and IgG1 in asthma and food allergy mouse models. The number of infiltrating cells in bronchoalveolar lavage fluid was reduced, and eosinophil infiltration in lungs was relieved by B. infantis CGMCC313-2 in allergic asthma mice. Body weight was regained in food allergy mice, and intestinal inflammation was attenuated by B. infantis CGMCC313-2. Following administration of B. infantis CGMCC313-2, the concentrations of interleukin-4 (IL-4) and IL-13 decreased in both allergic asthma and food allergy mice.
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| Publish Date |
2017-03-28 10:34 |
| Citation |
Liu MY, Yang ZY, Dai WK, Huang JQ, Li YH, Zhang J, Qiu CZ, Wei C, Zhou Q, Sun X, Feng X, Li DF, Wang HP, Zheng YJ. Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and b-lactoglobulin-induced intestinal food allergy mouse models. World J Gastroenterol 2017; 23(12): 2149-2158 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i12/2149.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i12.2149 |
