BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/20/2017 3:58:56 PM | Browse: 1179 | Download: 1598
Publication Name World Journal of Gastroenterology
Manuscript ID 31752
Country/Territory China
2016-12-06 11:07
Peer-Review Started
2016-12-06 21:09
To Make the First Decision
2016-12-29 09:11
Return for Revision
2016-12-30 10:34
2017-01-13 10:36
Second Decision
2017-02-15 21:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-17 13:11
Articles in Press
2017-02-17 13:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-03-21 23:40
Typeset the Manuscript
2017-04-11 11:11
Publish the Manuscript Online
2017-04-20 15:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published byBaishideng Publishing Group Inc.All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Clinical Trials Study
Article Title Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Shu Dong, Zong-Ying Zhan, Hong-Yan Cao, Chao Wu, Yan-Qin Bian, Jian-Yuan Li, Gen-Hong Cheng, Ping Liu and Ming-Yu Sun
Funding Agency and Grant Number
Funding Agency Grant Number
Major Project of Shanghai Municipal S&T Commission 15DZ1900104
National Natural Science Foundation 81273729
Corresponding Author Ming-yu Sun, MD, PhD, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New District, Shanghai 201203, China. mysun248@hotmail.com
Key Words Urinary metabonomics; Nonalcoholic fatty liver disease; Steatohepatitis
Core Tip To identify biomarkers that can distinguish between nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), urine and blood were obtained from patients with NAFLD and NASH, and healthy controls. Urinary metabonomics found differences in 31 metabolites between NAFLD and NASH, including nucleic acids and amino acids. Pathway analysis showed that pathways of energy metabolism, amino acid metabolism, and the pentose phosphate pathway, were closely associated with the pathological processes in NAFLD and NASH. These biomarkers could distinguish between NAFLD and NASH, and could help to determine the mechanism involved in the development of NASH from NAFLD.
Publish Date 2017-04-20 15:58
Citation Dong S, Zhan ZY, Cao HY, Wu C, Bian YQ, Li JY, Cheng GH, Liu P, Sun MY. Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease. World J Gastroenterol 2017; 23(15): 2771-2784
URL http://www.wjgnet.com/1007-9327/full/v23/i15/2771.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i15.2771
Full Article (PDF) WJG-23-2771.pdf
Full Article (Word) WJG-23-2771.doc
Manuscript File 31752-Review.docx
Answering Reviewers 31752-Answering reviewers.pdf
Audio Core Tip 31752-Audio core tip.wav
Biostatistics Review Certificate 31752-Biostatistics statement.pdf
Clinical Trial Registration Statement 31752-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 31752-Conflict-of-interest statement.pdf
Copyright License Agreement 31752-Copyright assignment.pdf
Data Sharing Statement 31752-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31752-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20161205155817.docx
Institutional Animal Care and Use Committee Approval Form or Document 31752-Institutional animal care and use committee statement.docx
Institutional Review Board Approval Form or Document 31752-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 31752-Language certificate.pdf
Scientific Research Process 31752-Scientific research process.pdf
Peer-review Report 31752-Peer-review(s).pdf
Scientific Misconduct Check 31372-Scientific misconduct check.pdf
Scientific Editor Work List 31752-Scientific editor work list.pdf