Publication Name	World Journal of Gastroenterology
Manuscript ID	32406
Country	Australia

Received	2017-01-06 13:33
Peer-Review Started	2017-01-09 08:23
To Make the First Decision	2017-03-16 11:33
Return for Revision	2017-03-17 15:06
Revised	2017-05-09 12:31
Second Decision	2017-06-27 06:06
Accepted by Journal Editor-in-Chief	2017-06-27 21:41
Accepted by Company Editor-in-Chief	2017-07-04 05:49
Articles in Press	2017-07-04 05:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-11 06:59
Publish the Manuscript Online	2017-08-19 11:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	cytoplasmic domain of tissue factor promotes liver fibrosis in mice
Manuscript Source	Invited Manuscript
All Author List	Virginia Knight, Dinushka Lourenz, Jorge Tchongue, Jeanne Correia, Peter Tipping and William Sievert
Funding Agency and Grant Number
Corresponding Author	William Sievert, MD, Director, Professor, Gastroenterology and Hepatology Unit, Monash Health, 246 Clayton Road, Melbourne 3168, Victoria, Australia. william.sievert@monash.edu
Key Words	Tissue factor; protease activated receptor; Hepatic stellate cell; liver fibrosis; macrophage
Core Tip	No effective anti-fibrotic therapies are avail­able for patients with cirrhosis. PAR-2, a receptor that activates coagulation and inflammation, promotes hepatic fibrosis; whether tissue factor (TF), the primary initiator of the coagulation cascade, affects hepatic fibrosis is unknown. We found that deletion of the TF cytoplasmic domain reduces fibrosis through an effect on hepatic stellate cell activation, possibly mediated through reduced hepatic macrophage activation. Currently available direct thrombin inhibitors may be useful in preventing hepatic fibrosis while therapeutic targeting of the cytoplasmic domain of TF may be useful in patients with advanced liver disease, as its deletion does not alter coagulation.
Publish Date	2017-08-19 11:33
Citation	Knight V, Lourensz D, Tchongue J, Correia J, Tipping P, Sievert W. cytoplasmic domain of tissue factor promotes liver fibrosis in mice. World J Gastroenterol 2017; 23(31): 5692-5699
URL	http://www.wjgnet.com/1007-9327/full/v23/i31/5692.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i31.5692

Full Article (PDF)	WJG-23-5692.pdf
Full Article (Word)	WJG-23-5692.doc
Manuscript File	32406-Review.docx
Answering Reviewers	32406-Answering reviewers.pdf
Audio Core Tip	32406-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	32406-Conflict-of-interest statement.pdf
Copyright License Agreement	32406-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	32406-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20170106133027.pdf
Peer-review Report	32406-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	32406-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	32406-Scientific misconduct check.pdf
Scientific Editor Work List	32406-Scientific editor work list.pdf