| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Role of the advanced glycation end products receptor in Crohn’s disease inflammation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Rachele Ciccocioppo, Alessandro Vanoli, Catherine Klersy, Venerina Imbesi, Vincenzo Boccaccio, Rachele Manca, Elena Betti, Giuseppina Cristina Cangemi, Elena Strada, Roberta Besio, Antonio Rossi, Colomba Falcone, Sandro Ardizzone, Paolo Fociani, Piergiorgio Danelli and Gino Roberto Corazza |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Direzione Scientifica, Fondazione IRCCS Policlinico San Matteo-Progetto di Ricerca Corrente |
08061307/11 |
|
| Corresponding Author |
Rachele Ciccocioppo, MD, Department of Internal Medicine, Center for the Study and Cure of Inflammatory Bowel Disease, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy. rachele.ciccocioppo@unipv.it |
| Key Words |
Apoptosis; Crohn’s disease; Chronic inflammation; Immunohistochemistry; Receptor for advanced glycation end products; Tumor necrosis factor-α |
| Core Tip |
Receptor for the advanced glycation end products (RAGE) is a multiligand transmembrane receptor whose activation sustains chronic inflammation. The inhibition of RAGE-ligand interaction has proved successful in an experimental model of Crohn’s disease (CD). Our work shows an up-regulation of RAGE expression in both inflamed and non-inflamed mucosa of CD patients in comparison to healthy tissue from control subjects. Moreover, RAGE blocking significantly affects both the apoptotic rate and tumor necrosis factor-α secretion of mucosal immune cells, which are considered to be leading mechanisms in the chronic inflammation of CD. These findings pave the way for a possible use of RAGE blocking agents as a new therapeutic tool in this disabling condition.
|
| Publish Date |
2013-12-18 10:39 |
| Citation |
Ciccocioppo R, Vanoli A, Klersy C, Imbesi V, Boccaccio V, Manca R, Betti E, Cangemi GC, Strada E, Besio R, Rossi A, Falcone C, Ardizzone S, Fociani P, Danelli P, Corazza GR. Role of the advanced glycation end products receptor in Crohn’s disease inflammation. World J Gastroenterol 2013; 19(45): 8269-8281 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i45/8269.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i45.8269 |
