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8/18/2017 2:46:28 AM | Browse: 451 | Download: 559
Publication Name World Journal of Experimental Medicine
Manuscript ID 32948
Country/Territory Bulgaria
2017-01-30 16:52
Peer-Review Started
2017-02-08 14:18
To Make the First Decision
2017-05-10 17:18
Return for Revision
2017-05-11 17:32
2017-05-26 08:57
Second Decision
2017-06-22 02:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-03 02:32
Articles in Press
2017-07-03 02:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-15 09:28
Publish the Manuscript Online
2017-08-18 02:46
ISSN 2220-315x (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Basic Study
Article Title Treg/Th17 cell balance and phytohaemagglutinin activation of T lymphocytes in peripheral blood of systemic sclerosis patients
Manuscript Source Invited Manuscript
All Author List Ekaterina Krasimirova, Tsvetelina Velikova, Ekaterina Ivanova-Todorova, Kalina Tumangelova-Yuzeir, Desislava Kalinova, Vladimira Boyadzhieva, Nikolay Stoilov, Tsvetelina Yoneva, Rasho Rashkov and Dobroslav Kyurkchiev
Funding Agency and Grant Number
Corresponding author Dobroslav Kyurkchiev, DSc, MD, PhD, Associate Professor, Laboratory of Clinical immunology, University Hospital “St. Ivan Rilski”, Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, Ivan Geshov Str. 15, Sofia 1431, Bulgaria. dkyurkchiev@medfac.mu-sofia.bg
Key Words Systemic sclerosis; T-cell activation; Th17; Tregs; CD4+CD25-Foxp3+ cells; Interleukin-17; Tissue growth factor-b; Interleukin-10; Interleukin-6
Core Tip Systemic sclerosis (SSc) is a devastating autoimmune disorder, which can be subclassified into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) based on the skin manifestations. One of the original contributions of our study has demonstrated a decreased capacity for PHA-induced peripheral T-cell activation in patients with SSc. For the first time, our research group has identified an up-regulated percentage of CD4+CD25-FoxP3+ cells in the dcSSc subset. Regarding the peripheral cytokine profile in SSc, the serum levels of interleukin (IL)-17A have been increased in lcSSc as opposed to the dcSSc subset. The rest of our data, concerning the elevated circulating IL-6, IL-10, and TGF-b in SSc patients, has confirmed literature-based results.
Publish Date 2017-08-18 02:46
Citation Krasimirova E, Velikova T, Ivanova-Todorova E, Tumangelova-Yuzeir K, Kalinova D, Boyadzhieva V, Stoilov N, Yoneva T, Rashkov R, Kyurkchiev D. Treg/Th17 cell balance and phyto¬haemagglutinin activation of T lymphocytes in peripheral blood of systemic sclerosis patients. World J Exp Med 2017; 7(3): 84-96
Url http://www.wjgnet.com/2220-315X/full/v7/i3/84.htm
DOI http://dx.doi.org/10.5493/wjem.v7.i3.84
Full Article (PDF) WJEM-7-84.pdf
Full Article (Word) WJEM-7-84.doc
Manuscript File 32948-Review.doc
Answering Reviewers 32948-Answering reviewers.pdf
Audio Core Tip 32948-Audio core tip.mp3
Biostatistics Review Certificate 32948-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 32948-Conflict-of-interest statement.pdf
Copyright License Agreement 32948-Copyright assignment.pdf
Data Sharing Statement 32948-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 32948-Institutional animal care and use committee.pdf
Institutional Review Board Approval Form or Document 32948-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 32948-Language certificate.pdf
Scientific Research Process 32948-Scientific research process.pdf
Peer-review Report 32948-Peer-review(s).pdf
Scientific Misconduct Check 32948-Scientific misconduct check.pdf
Scientific Editor Work List 32948-Scientific editor work list.pdf