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6/26/2017 10:23:06 AM | Browse: 1096 | Download: 1477
Publication Name World Journal of Gastroenterology
Manuscript ID 32967
Country/Territory Slovakia
Received
2017-02-01 12:45
Peer-Review Started
2017-02-02 13:45
To Make the First Decision
2017-03-16 13:18
Return for Revision
2017-03-20 16:51
Revised
2017-03-27 20:53
Second Decision
2017-05-18 03:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-19 07:59
Articles in Press
2017-05-19 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-21 02:46
Publish the Manuscript Online
2017-06-26 10:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pharmacology & Pharmacy
Manuscript Type Basic Study
Article Title Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells
Manuscript Source Invited Manuscript
All Author List Viera Tischlerova, Martin Kello, Mariana Budovska and Jan Mojzis
Funding Agency and Grant Number
Funding Agency Grant Number
Grants of the Slovak Grant Agency for Science VEGA 1/0322/14
Grants of the Slovak Grant Agency for Science VEGA 1/0753/17
Corresponding Author Jan Mojzis, Professor, DVM, DSc, Department of Pharmacology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovak Republic. jan.mojzis@upjs.sk
Key Words Colorectal carcinoma; Indole phytoalexins; Antiproliferative; Apoptosis; Intrinsic pathway
Core Tip In this study we inform about our first results obtained from cell proliferation assays, flow cytometry analysis and Western blot analysis of HCT116 cells after treatment with compound K-453, which belongs to a group of synthetic derivatives of indole phytoalexins originally isolated from cruciferous vegetables. This study demonstrates that our compound induces the mitochondrial pathway of apoptosis and that the antiproliferative effect of our substance may be linked to inhibition of several signaling pathways. Our results provide a rationale for further in vivo anticancer efficacy studies.
Publish Date 2017-06-26 10:23
Citation Tischlerova V, Kello M, Budovska M, Mojzis J. Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells. World J Gastroenterol 2017; 23(24): 4341-4353
URL http://www.wjgnet.com/1007-9327/full/v23/i24/4341.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i24.4341
Full Article (PDF) WJG-23-4341.pdf
Full Article (Word) WJG-23-4341.doc
Manuscript File 32967-Review.docx
Answering Reviewers 32967-Answering reviewers.pdf
Audio Core Tip 32967-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 32967-Conflict-of-interest statement.pdf
Copyright License Agreement 32967-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32967-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 32967-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 32967-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 32967-Language certificate.pdf
Peer-review Report 32967-Peer-review(s).pdf
Scientific Misconduct Check 32967-Scientific misconduct check.pdf
Scientific Editor Work List 32967-Scientific editor work list.pdf