| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Observational Study |
| Article Title |
Histopathological analysis of infiltrating T cell subsets in acute T cell-mediated rejection in the kidney transplant
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Francisco Salcido-Ochoa, Susan Swee-Shan Hue, Siyu Peng, Zhaoxiang Fan, Reiko Lixiang Li, Jabed Iqbal, John Carson Allen Jr and Alwin Hwai Liang Loh |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Kidney Foundation Singapore |
NKFRC/2008/07/22 |
| Medicine Academic Clinical Program (a SingHealth-Duke/National University of Singapore Joint Partnership) |
|
| Khoo Scholar Programme (Duke/National University of Singapore) |
|
|
| Corresponding Author |
Dr. Francisco Salcido-Ochoa, MD (Mex), MRCP (UK), MSc (UK), PhD (UK), Consultant and Transplant Immunologist, Tregs and HLA Research Force and Renal Medicine Department, Singapore General Hospital, 20 college Road, Academia, Level 3, Singapore 169856, Singapore. francisco.salcido.ochoa@singhealth.com.sg |
| Key Words |
Acute T cell-mediated rejection in the kidney transplant; Banff classification; Cytotoxic T cell; Regulatory T cell; Th17 cell |
| Core Tip |
In the clinical setting, acute T cell-mediated rejection in the kidney transplant (ATCMR-KTx) is only confirmed through a kidney transplant biopsy, which is scored according to the Banff classification. The Banff classification is largely based on the estimation of mononuclear cell infiltration instead of the identification and quantification of the actual T cell subsets recruited to mediate rejection. Therefore, a more detailed an¬alysis of the inflammatory infiltrate of ATCMR-KTx is likely to enhance the diagnostic accuracy of the Banff classification. In our analyses, ATCMR-KTx appeared to be characterised by a numerical dominance of cytotoxic T lymphocytes over regulatory T cells in comparison to the absence of acute rejection. We also found an association of the numbers of infiltrating Th17 cells with kidney transplant outcomes. Although this is a small pilot study, it further supports our suspicion that the immune balance in ATCMR-KTx is tilted towards the pro-rejection forces. |
| Publish Date |
2017-08-22 07:27 |
| Citation |
Salcido-Ochoa F, Hue SSS, Peng S, Fan Z, Li RL, Iqbal J, Allen Jr JC, Loh AHL. Histopathological analysis of infiltrating T cell subsets in acute T cell-mediated rejection in the kidney transplant. World J Transplant 2017; 7(4): 222-234 |
| URL |
http://www.wjgnet.com/2220-3230/full/v7/i4/222.htm |
| DOI |
http://dx.doi.org/10.5500/wjt.v7.i4.222 |
