Publication Name	World Journal of Gastroenterology
Manuscript ID	33194
Country	Italy

Received	2017-02-07 16:15
Peer-Review Started	2017-02-10 09:59
To Make the First Decision	2017-02-23 09:19
Return for Revision	2017-02-27 10:56
Revised	2017-03-11 17:42
Second Decision	2017-03-17 17:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-03-20 16:42
Articles in Press	2017-03-20 16:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-12 14:02
Publish the Manuscript Online	2017-04-20 15:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Is there still a role for the hepatic locoregional treatment of metastatic neuroendocrine tumors in the era of systemic targeted therapies?
Manuscript Source	Invited Manuscript
All Author List	Federica Cavalcoli, Emanuele Rausa, Dario Conte, Antonio Federico Nicolini and Sara Massironi
Funding Agency and Grant Number
Corresponding Author	Federica Cavalcoli, MD, Gastroenterology and Endoscopic Unit, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milano, Italy. cavalcoli.federica@gmail.com
Key Words	Gastroenteropancreatic neuroendocrine neoplasms; Liver metastases; Locoregional therapies; Systemic therapies; Ablation; Chemoembolization
Core Tip	Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) frequently present with distant metastases. In the last years, a number of treatment has become available for advanced GEP-NENs and the optimal management for these patients remains to be established. While systemic medical therapies and peptide receptor radionuclide therapy represent effective options, they are usually palliative whereas liver-directed treatments often represent the only possibly curative therapy, even if not supported by prospective trials. Considering the lack of randomized trials comparing locoregional treatments in advanced GEP-NEN, clinical judgment remains key to set the most appropriate therapeutic pathway. Prospective data may lead to more personalized and optimized treatments.
Publish Date	2017-04-20 15:58
Citation	Cavalcoli F, Rausa E, Conte D, Nicolini AF, Massironi S. Is there still a role for the hepatic locoregional treatment of metastatic neuroendocrine tumors in the era of systemic targeted therapies? World J Gastroenterol 2017; 23(15): 2640-2650
URL	http://www.wjgnet.com/1007-9327/full/v23/i15/2640.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i15.2640

Full Article (PDF)	WJG-23-2640.pdf
Full Article (Word)	WJG-23-2640.doc
Manuscript File	33194-Review.docx
Answering Reviewers	33194-Answering reviewers.pdf
Audio Core Tip	33194-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33194-Conflict-of-interest statement.pdf
Copyright License Agreement	33194-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	33194-Language certificate.pdf
Peer-review Report	33194-Peer-review(s).pdf
Scientific Misconduct Check	33194-Scientific misconduct check.pdf
Scientific Editor Work List	33194-Scientific editor work list.pdf