BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/20/2017 12:12:52 PM | Browse: 909 | Download: 1915
Publication Name World Journal of Gastroenterology
Manuscript ID 33218
Country/Territory Italy
Received
2017-02-07 18:49
Peer-Review Started
2017-02-10 08:37
To Make the First Decision
2017-03-16 11:51
Return for Revision
2017-03-21 11:36
Revised
2017-04-03 15:41
Second Decision
2017-04-27 18:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-04 18:31
Articles in Press
2017-05-04 18:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-05-15 03:58
Typeset the Manuscript
2017-06-10 09:42
Publish the Manuscript Online
2017-06-20 12:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pharmacology & Pharmacy
Manuscript Type Basic Study
Article Title Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model
Manuscript Source Invited Manuscript
All Author List Chiara Dianzani, Federica Foglietta, Benedetta Ferrara, Arianna Carolina Rosa, Elisabetta Muntoni, Paolo Gasco, Carlo Della Pepa, Roberto Canaparo and Loredana Serpe
Funding Agency and Grant Number
Funding Agency Grant Number
Regione Piemonte (grant “Converging Technologies”, NanoIGT) and University of Torino (grant “Ricerca Locale”, Linea A)
Corresponding Author Loredana Serpe, MD, PhD, Dipartimento di Scienza e Tecnologia del Farmaco, University of Torino, Via Pietro Giuria 13, 10125 Torino, Italy. loredana.serpe@unito.it
Key Words Nanoparticles; Dexamethasone; Butyrate; Inflammatory bowel disease; Drug delivery systems
Core Tip The oral treatment with dexamethasone and butyrate co-loaded into nanoparticles was effective in achieving strong anti-inflammatory effects at doses significantly lower than those required for each single drug. This nanoformulation may open a new window on the treatment of chronic inflammatory conditions such as inflammatory bowel disease, where dose- and time-dependent side effects can limit the drug’s therapeutic usefulness. Notably, dexamethasone cholesteryl butyrate-solid lipid nanoparticles significantly relieved and repaired colon inflammation in a colitis mouse model thanks to the nanoformulation, which displayed an additive synergism among the corticosteroid, dexamethasone, and the short-chain fatty acid, butyrate.
Publish Date 2017-06-20 12:12
Citation Dianzani C, Foglietta F, Ferrara B, Rosa AC, Muntoni E, Gasco P, Della Pepa C, Canaparo R, Serpe L. Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model. World J Gastroenterol 2017; 23(23): 4200-4210
URL http://www.wjgnet.com/1007-9327/full/v23/i23/4200.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i23.4200
Full Article (PDF) WJG-23-4200.pdf
Full Article (Word) WJG-23-4200.doc
Manuscript File 33218-Review.doc
Answering Reviewers 33218-Answering reviewers.pdf
Audio Core Tip 33218-Audio core tip.mp3
Biostatistics Review Certificate 33218-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33218-Conflict-of-interest statement.pdf
Copyright License Agreement 33218-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20170129052000.pdf
Institutional Animal Care and Use Committee Approval Form or Document 33218-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 33218-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 33218-Language certificate.pdf
Peer-review Report 33218-Peer-review(s).pdf
Scientific Misconduct Check 33218-Scientific misconduct check.pdf
Scientific Editor Work List 33218-Scientific editor work list.pdf