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Articles Published Processes
1/10/2018 7:12:07 AM | Browse: 976 | Download: 1453
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Received |
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2017-02-08 10:15 |
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Peer-Review Started |
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2017-02-12 16:43 |
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To Make the First Decision |
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2017-05-10 17:21 |
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Return for Revision |
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2017-05-17 08:51 |
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Revised |
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2017-08-30 08:02 |
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Second Decision |
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2017-11-28 08:26 |
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Accepted by Journal Editor-in-Chief |
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2017-11-28 09:27 |
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Accepted by Company Editor-in-Chief |
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2017-12-05 03:14 |
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Articles in Press |
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2017-12-05 03:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-01-09 03:41 |
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Publish the Manuscript Online |
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2018-01-10 07:12 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Short-term effects of obestatin on hexose uptake and triacylglycerol breakdown in human subcutaneous adipocytes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Christian Carpéné, Francisco Les, David Estève and Jean Galitzky |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Erasmus plus Traineeship program |
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| Corresponding Author |
Christian Carpéné, Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse, CHU Rangueil, UPS, Toulouse 31432, France. christian.carpene@inserm.fr |
| Key Words |
Insulin; Lipolysis; Adipokines; Glucose up¬take; Obestatin; Human adipocytes |
| Core Tip |
We have compared in adipocytes the well-known glucose uptake stimulation and lipolysis inhibition induced by insulin to the effects of obestatin, a gut peptide derived from ghrelin gene recently proposed to act on fat cells. Obestatin was much less efficient than insulin in adipocytes from human abdominal subcutaneous adipose tissue. Indeed, obestatin weakly activated hexose transport while it could not reproduce the antilipolytic effect of insulin at any tested concentration. We therefore propose that obestatin does not rapidly modulate lipogenesis and lipolysis and that its contribution to energy homeostasis depends on actions other than a direct control of adipocyte metabolism. |
| Publish Date |
2018-01-10 07:12 |
| Citation |
Carpéné C, Les F, Estève D, Galitzky J. Short-term effects of obestatin on hexose uptake and triacylglycerol breakdown in human subcutaneous adipocytes. World J Diabetes 2018; 9(1): 25-32 |
| URL |
http://www.wjgnet.com/1948-9358/full/v9/i1/25.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v9.i1.25 |
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