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5/18/2017 4:11:31 AM | Browse: 925 | Download: 1686
Publication Name World Journal of Biological Chemistry
Manuscript ID 33436
Country/Territory United States
Received
2017-02-08 09:20
Peer-Review Started
2017-02-12 16:52
To Make the First Decision
2017-03-08 09:43
Return for Revision
2017-03-10 17:25
Revised
2017-04-03 22:09
Second Decision
2017-04-29 16:49
Accepted by Journal Editor-in-Chief
2017-04-29 16:55
Accepted by Company Editor-in-Chief
2017-05-05 18:29
Articles in Press
2017-05-05 18:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-16 01:39
Publish the Manuscript Online
2017-05-18 04:11
ISSN 1949-8454 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Basic Study
Article Title Identification of neuron selective androgen receptor inhibitors
Manuscript Source Invited Manuscript
All Author List Maya Otto-Duessel, Ben Yi Tew, Steven Vonderfecht, Roger Moore and Jeremy O Jones
Funding Agency and Grant Number
Corresponding Author Jeremy O Jones, PhD, Assistant Professor, Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Rd, Beckman 2310, Duarte, CA 91010, United States. jjones@coh.org
Key Words Androgen receptor; Selective androgen receptor modulator; Spinal and bulbar muscular atrophy; Kennedy’s disease
Core Tip Kennedy’s disease is caused by genetic expansion of the polyglutamine tract in the androgen receptor (AR). There is debate over whether the toxicity is due to expression of this mutant AR in motor neurons, muscle cells, or both. We have identified neuron-specific AR inhibitors, which could be used to help answer this question, and might be useful in the treatment or prevention of Kennedy’s disease. These inhibitors function via FOXM1 and beta-catenin, which are shown to have important roles in the regulation of AR in neurons.
Publish Date 2017-05-18 04:11
Citation Otto-Duessel M, Tew BY, Vonderfecht S, Moore R, Jones JO. Identification of neuron selective androgen receptor inhibitors. World J Biol Chem 2017; 8(2): 138-150
URL http://www.wjgnet.com/1949-8454/full/v8/i2/138.htm
DOI http://dx.doi.org/10.4331/wjbc.v8.i2.138
Full Article (PDF) WJBC-8-138.pdf
Full Article (Word) WJBC-8-138.doc
Manuscript File 33436-Review.doc
Answering Reviewers 33436-Answering reviewers.pdf
Audio Core Tip 33436-Audio core tip.mp3
Biostatistics Review Certificate Biostatistics_Statement_20170208011421.doc
Conflict-of-Interest Disclosure Form 33436-Conflict-of-interest statement.pdf
Copyright License Agreement 33436-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) Grant_Application_Form_20170208011338.doc
Institutional Animal Care and Use Committee Approval Form or Document 33436-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 33436-Institutional review board statement.pdf
Peer-review Report 33436-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 33436-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 33436-Scientific misconduct check.pdf
Scientific Editor Work List 33436-Scientific editor work list.pdf