BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
7/28/2017 8:16:18 AM | Browse: 1007 | Download: 1368
Publication Name World Journal of Gastroenterology
Manuscript ID 33465
Country/Territory China
Received
2017-02-10 09:07
Peer-Review Started
2017-02-14 16:39
To Make the First Decision
2017-03-30 13:25
Return for Revision
2017-03-31 16:00
Revised
2017-04-13 18:38
Second Decision
2017-05-04 17:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-09 16:59
Articles in Press
2017-05-09 16:59
Publication Fee Transferred
2017-06-20 02:22
Edit the Manuscript by Language Editor
2017-07-09 22:50
Typeset the Manuscript
2017-07-20 09:28
Publish the Manuscript Online
2017-07-28 08:16
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biology
Manuscript Type Basic Study
Article Title Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer
Manuscript Source Unsolicited Manuscript
All Author List Jia-Chi Ma, Xiao-Wen Sun, He Su, Quan Chen, Tian-Kang Guo, Yuan Li, Xiao-Chang Chen, Jin Guo, Zhen-Qiang Gong, Xiao-Dan Zhao and Jian-Bo Qi
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81260325 (to Ma JC)
Corresponding Author Jia-Chi Ma, PhD, Department of General Surgery, Gansu Provincial People's Hospital, 204 Dong Gang West Road, Lanzhou 730000, Gansu Province, China. tsmjc@hotmail.com
Key Words CXCL12/SDF-1α; CXCL6; Metastasis; PI3K/Akt/mTOR pathway; Colon cancer
Core Tip This study has provided the first report of fibroblast-derived CXCL12 enhancement of CXCL6 secretion in colon cancer cells, and of both CXCL12 and CXCL6 co-operatively regulating metastasis through the PI3K/Akt/mTOR signaling pathway. Blockage of this pathway may be a potential anti-metastatic therapeutic target for patients with colon cancer. Our work might encourage further investigation into more potent angiogenesis modulating agents to improve the effectiveness of colon cancer therapies.
Publish Date 2017-07-28 08:16
Citation Ma JC, Sun XW, Su H, Chen Q, Guo TK, Li Y, Chen XC, Guo J, Gong ZQ, Zhao XD, Qi JB. Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer. World J Gastroenterol 2017; 23(28): 5167-5178
URL http://www.wjgnet.com/1007-9327/full/v23/i28/5167.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i28.5167
Full Article (PDF) WJG-23-5167.pdf
Full Article (Word) WJG-23-5167.doc
Manuscript File 33465-Review.doc
Answering Reviewers 33465-Answering reviewers.pdf
Audio Core Tip 33465-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 33465-Conflict-of-interest statement.pdf
Copyright License Agreement 33465-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 33465-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 33465-Language certificate.pdf
Peer-review Report 33465-Peer-review(s).pdf
Scientific Misconduct Check 33465-Scientific misconduct check.pdf
Scientific Editor Work List 33465-Scientific editor work list.pdf