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9/14/2017 3:13:08 AM | Browse: 93 | Download: 177
Publication Name World Journal of Gastroenterology
Manuscript ID 33611
Country of Manuscript Source China
2017-02-22 15:24
Peer-Review Started
2017-02-28 11:35
To Make the First Decision
2017-06-22 00:39
Return for Revision
2017-06-23 10:38
2017-07-07 14:15
Second Decision
2017-08-02 00:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-08-08 05:42
Articles in Press
2017-08-08 05:42
Publication Fee Transferred
2017-08-14 06:27
Edit the Manuscript by Language Editor
2017-08-30 01:09
Typeset the Manuscript
2017-09-05 01:32
Publish the Manuscript Online
2017-09-14 03:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Medicine, Research and Experimental
Manuscript Type Basic Study
Article Title Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats
Manuscript Source Unsolicited Manuscript
All Author List Zhi-Yuan Li, Yan Huang, Yan-Ting Yang, Dan Zhang, Yan Zhao, Jue Hong, Jie Liu, Li-Jie Wu, Cui-Hong Zhang, Huan-Gan Wu, Ji Zhang and Xiao-Peng Ma
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81273843
National Natural Science Foundation of China 81674073
National Key Basic Research Program of China (973 Program) 2015CB554501
Project of Shanghai Municipal Commission of Health and Family Planning 20144Y0153
Project of Shanghai Municipal Commission of Health and Family Planning 017BR047
Correspondence To Xiao-Peng Ma, PhD, Research Fellow, Shanghai Research Institute of Acupuncture and Meridian, No. 650 South Wanping Road, Xuhui District, Shanghai 200030, China. pengpengma@163.com
Keywords Herb-partitioned moxibustion; Chronic inflammatory visceral pain; Pain behavior; Analgesia; MEK; Extracellular signal-regulated kinase; cAMP response element binding protein; Signaling pathway
Core Tip chronic inflammatory visceral pain (CIVP) (abdominal pain) is one of the major symptoms of inflammatory bowel disease. Herb-partitioned moxibustion (HPM) at bilateral Tianshu (ST25) and Qihai (CV6) acupoints was effective in enhancing the pain threshold and easing pain in CIVP rats. Levels of phosphorylated protein and mRNA expression of mitogen-activated extracellular signal-regulated kinase 1, extracellular signal-regulated kinase and cAMP response element binding protein were abnormally increased in the spinal cord of CIVP rats. HPM effectively down-regulated the abnormally increased expression, which is possibly one of the analgesic mechanisms of HPM.
Publish Date 2017-09-14 03:13
Citation Li ZY, Huang Y, Yang YT, Zhang D, Zhao Y, Hong J, Liu J, Wu LJ, Zhang CH, Wu HG, Zhang J, Ma XP. Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats. World J Gastroenterol 2017; 23(34): 6220-6230
Url http://www.wjgnet.com/1007-9327/full/v23/i34/6220.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i34.6220
Full Article (PDF) WJG-23-6220.pdf
Full Article (Word) WJG-23-6220.doc
Revised Manuscript 33611-Review.doc
Peer-review Report 33611-Peer-review(s).pdf
Answering Reviewers 33611-Answering reviewers.pdf
Scientific Misconduct Check 33611-Scientific misconduct check.pdf
Scientific Editor Work List 33611-Scientific editor work list.pdf
Audio Core Tip 33611-Audio core tip.MP3
Biostatistics Review Certificate 33611-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33611-Conflict-of-interest statemen.pdf
Copyright License Agreement 33611-Copyright assignment.pdf
Data Sharing Statement 33611-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 33611-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 33611-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 33611-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 33611-Language certificate.pdf
Scientific Research Process 33611-Scientific research process.pdf