| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Atsushi Iraha, Hiroshi Chinen, Akira Hokama, Takumi Yonashiro, Tetsu Kinjo, Kazuto Kishimoto, Manabu Nakamoto, Tetsuo Hirata, Nagisa Kinjo, Futoshi Higa, Masao Tateyama, Fukunori Kinjo and Jiro Fujita |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Akira Hokama, MD, PhD, Assistant Professor, Department of Infectious, Respiratory, and Digestive Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. hokama-a@med.u-ryukyu.ac.jp
|
| Key Words |
Fucoidan; Tight junction; Intestinal epithelial cells; Oxidative stress; Inflammatory bowel diseases |
| Core Tip |
The oxidative stress-induced disruption of the intestinal epithelial cells and subsequent increased paracellular permeability are critically important in the pathogenesis of inflammatory bowel diseases (IBD). A growing body of experimental evidence indicates that fucoidan, a dietary substance of fucose-enriched sulfated polysaccharides, display a wide variety of pharmacological anti-inflammatory activities. This study demonstrates that fucoidan protected the epithelial barrier function from oxidative injury of the tight junction as well as barrier disruption by upregulating the expression of claudin-1. Thus, fucoidan may be an appropriate therapy for the treatment of IBD. |
| Publish Date |
2013-09-09 09:30 |
| Citation |
Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, Nakamoto M, Hirata T, Kinjo N, Higa F, Tateyama M, Kinjo F, Fujita J. Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1. World J Gastroenterol 2013; 19(33): 5500-5507 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i33/5500.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i33.5500 |
